| Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis. | |
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MedLine Citation:
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PMID: 21048365 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function. |
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Authors:
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Shusuke Yagi; Masashi Akaike; Takashi Iwase; Kenya Kusunose; Toshiyuki Niki; Koji Yamaguchi; Kunihiko Koshiba; Sumiko Yoshida; Yuka Sumitomo-Ueda; Ken-ichi Aihara; Yoichiro Hirata; Munkhbaatar Dagvasumberel; Yoshio Taketani; Noriko Tomita; Hirotsugu Yamada; Takeshi Soeki; Tetsuzo Wakatsuki; Toshio Matsumoto; Masataka Sata |
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Publication Detail:
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Type: Journal Article Date: 2010-11-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 2309-12 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima. syagi@clin.med.tokushima-u.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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