| Borrelia burgdorferi reactivity in patients with severe persistent fatigue who are from a region in which Lyme disease is endemic. | |
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MedLine Citation:
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PMID: 8148448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Borrelia burgdorferi is the pathogen that causes Lyme disease. Patients frequently experience fatigue and malaise that can persist after antibiotic treatment. This study examined serological reactivity to B. burgdorferi in patients with chronic fatigue who were from a region in which Lyme disease is endemic. Blood and CSF were collected from patients without a history of infection due to B. burgdorferi (n = 12) and patients with persistent fatigue after antibiotic treatment of Lyme disease (n = 13). Serum and CSF were examined by ELISA for antibodies to B. burgdorferi, and routine studies of CSF were done. In the first group, one patient (8%) was seropositive; no patients had detectable antibodies in CSF. In the second group, nine patients (69%) were seropositive or borderline seropositive; seven (54%) had detectable antibodies in CSF. Unexplained abnormalities in CSF were noted in 42% and 31% of patients in each group, respectively. In this study positive serologies for Lyme disease were not found at a higher than expected rate for patients from a region of Lyme disease endemicity who had idiopathic chronic fatigue. Fatigued patients did show a surprisingly high rate of unexplained minor CSF abnormalities suggestive of CNS or meningeal dysfunction. |
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Authors:
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P K Coyle; L B Krupp; C Doscher; K Amin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 18 Suppl 1 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-05-12 Completed Date: 1994-05-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S24-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Health Sciences Center, SUNY, Stony Brook 11794. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antibodies, Bacterial / blood, cerebrospinal fluid Borrelia burgdorferi Group / immunology*, pathogenicity* Central Nervous System Diseases / complications Fatigue Syndrome, Chronic / cerebrospinal fluid, etiology*, microbiology Female Humans Lyme Disease / complications* Male Meninges Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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AI 31561/AI/NIAID NIH HHS; AR40470/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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