Document Detail


Boron-11 MRI and MRS of intact animals infused with a boron neutron capture agent.
MedLine Citation:
PMID:  3210959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Boron neutron capture therapy (BNCT) depends on the delivery of boron-containing drugs to a targeted lesion. Currently, the verification and quantification of in vivo boron content is a difficult problem. Boron-11 spectroscopy was utilized to confirm the presence of a dimeric sulfhydryl dodecaborane BNCT agent contained in an intact animal. Spectroscopy experiments revealed that the decay time of transverse magnetization of the boron-11 spins was less than 1 ms which precluded the use of a 2DFT imaging protocol. A back-projection protocol was developed and utilized to generate the first boron-11 image of a BNCT agent in the liver of an intact Fisher 344 rat.
Authors:
G W Kabalka; M Davis; P Bendel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  8     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-02-21     Completed Date:  1989-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Tennessee Institute for Biomedical Imaging, Knoxville 37920.
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MeSH Terms
Descriptor/Qualifier:
Animals
Borates / analysis*,  therapeutic use
Liver / analysis*
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Male
Neutrons*
Radiotherapy / methods
Rats
Rats, Inbred F344
Sulfides / analysis*,  therapeutic use
Chemical
Reg. No./Substance:
0/Borates; 0/Sulfides; 112504-58-2/cesium 1,1'-dithiobis(undecahydrododecaborate)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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