Document Detail


Bordetella pertussis, molecular pathogenesis under multiple aspects.
MedLine Citation:
PMID:  11173039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies, including those based on genomics, have demonstrated that besides toxins and adhesins, Bordetella pertussis uses many additional virulence determinants. Most of them are part of the BvgAS regulon, although some, in particular iron-uptake systems, are independent of BvgAS. They are regulated by iron, although in one case, the production of a siderophore receptor could be linked to the BvgAS regulon.
Authors:
C Locht; R Antoine; F Jacob-Dubuisson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in microbiology     Volume:  4     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  82-9     Citation Subset:  IM    
Affiliation:
INSERM U447, Institut Pasteur de Lille, 1 rue du Prof. Calmette, F-59019, Lille Cedex, France. camille.locht@pasteur-lille.fr
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MeSH Terms
Descriptor/Qualifier:
Adhesins, Bacterial / genetics,  immunology
Antigens, Bacterial / metabolism
Bacterial Proteins / genetics,  metabolism
Bacterial Toxins / metabolism
Bordetella pertussis / pathogenicity*
Hemagglutinins / genetics,  immunology
Humans
Iron / metabolism
Lipopolysaccharides / metabolism
Signal Transduction
Transcription Factors / genetics,  metabolism
Virulence
Virulence Factors, Bordetella*
Chemical
Reg. No./Substance:
0/Adhesins, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Bacterial Toxins; 0/BvgA protein, Bacteria; 0/Hemagglutinins; 0/Lipopolysaccharides; 0/Transcription Factors; 0/Virulence Factors, Bordetella; 0/bvgS protein, Bordetella pertussis; 0/filamentous hemagglutinin adhesin, Bordetella pertussis; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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