Document Detail

Bordetella pertussis infection induces a mucosal IL-17 response and long-lived Th17 and Th1 immune memory cells in nonhuman primates.
MedLine Citation:
PMID:  23187316     Owner:  NLM     Status:  MEDLINE    
Despite near universal vaccine coverage, the bacterial pathogen Bordetella pertussis has re-emerged as a major public health concern. We recently developed a baboon (Papio anubis) model of pertussis that provides an excellent model of human pertussis. Using this model, the immune response to pertussis was characterized by measuring cytokines in the nasopharyngeal mucosa of infected baboons. Notably, we observed mucosal expression of interleukin-17 (IL-17) as well as IL-6, IL-23, and several cytokines and chemokines that are orchestrated by IL-17 immune responses. We also found substantial populations of circulating B. pertussis-specific Th17 and Th1 cells in convalescent animals >2 years post-infection consistent with a role in immunological memory to pertussis. Collectively, these data shed important light on the innate and adaptive immune responses to pertussis in a primate infection model and suggest that Th17 and Th1 immune responses contribute to the immunity conferred by natural pertussis infection.
J M Warfel; T J Merkel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2012-11-28
Journal Detail:
Title:  Mucosal immunology     Volume:  6     ISSN:  1935-3456     ISO Abbreviation:  Mucosal Immunol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2014-01-16     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  101299742     Medline TA:  Mucosal Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  787-96     Citation Subset:  IM    
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MeSH Terms
Adaptive Immunity
Bordetella pertussis / immunology*
Cytokines / biosynthesis,  immunology
Immunity, Innate
Immunologic Memory*
Interleukin-17 / immunology*,  metabolism
Nasal Mucosa / immunology,  metabolism
Respiratory Mucosa / immunology*,  metabolism
Th1 Cells / immunology*,  metabolism
Th17 Cells / immunology*,  metabolism
Whooping Cough / immunology*,  metabolism
Grant Support
5R24RR016556-10/RR/NCRR NIH HHS; P40 OD010988/OD/NIH HHS; P40 RR012317/RR/NCRR NIH HHS; P40RR012317/RR/NCRR NIH HHS; Y1-AI-1727-01/AI/NIAID NIH HHS
Reg. No./Substance:
0/Cytokines; 0/Interleukin-17

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