Document Detail


Border-cell migration: the race is on.
MedLine Citation:
PMID:  12511865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.
Authors:
Denise J Montell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  4     ISSN:  1471-0072     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-03     Completed Date:  2003-02-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-24     Citation Subset:  IM    
Affiliation:
Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, USA. dmontell@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement / physiology*
Drosophila melanogaster / cytology,  embryology*
Epithelial Cells / cytology*
Female
Gene Expression Regulation, Developmental
Ovary / cytology*
Signal Transduction / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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