Document Detail


Booster vaccination with recombinant hepatitis B vaccine four years after priming with one single dose.
MedLine Citation:
PMID:  10367949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We here studied the antibody response to a booster dose four years after the administration of one single dose of recombinant HB vaccine. Before receiving the booster dose, levels of protective antibodies (anti-HBs) were generally low and 24/41 (59%) individuals lacked detectable antibodies (< 1 IU/L). Within 14 d of booster vaccination, 36/38 (95%) vaccinees showed levels of antibodies > 100 IU/L. Notably, these levels were at least as high as those of a reference group 12 months after initiation of vaccination according to the standard three-dose vaccination at intervals of 0, 1 and 6 months. In conclusion, one single dose of HB vaccine seemed to confer on young healthy individuals a well preserved B cell memory, disclosed as a rapid and strong antibody response to a second dose four years later.
Authors:
J Wiström; C Ahlm; S Lundberg; B Settergren; A Tärnvik
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Vaccine     Volume:  17     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-27     Completed Date:  1999-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2162-5     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases, University Hospital of Umeå, Sweden. johan.wistrom@infdis.umu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Dose-Response Relationship, Immunologic
Female
Hepatitis B Antibodies / biosynthesis,  blood
Hepatitis B Vaccines / administration & dosage*,  immunology
Humans
Immunization Schedule
Immunization, Secondary*
Male
Vaccines, Synthetic / administration & dosage*,  immunology
Chemical
Reg. No./Substance:
0/Hepatitis B Antibodies; 0/Hepatitis B Vaccines; 0/Vaccines, Synthetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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