| Booster immunotherapy (BIT). | |
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MedLine Citation:
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PMID: 8198238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study tries to answer two questions: 1) how long does the therapeutic effect of successful immunotherapy (IT) last after termination of the treatment? and 2) what is the best treatment for recidivist patients? To answer the first question, we asked 108 patients with rye/grass pollen allergy who had previously undergone IT for 3-4 years and had responded well to treatment to complete a questionnaire on the course of their recovery after termination of the therapy. Evaluation of the answers revealed a recidivist rate of approximately 30% in the first 3 years. According to our results, the risk of a relapse after this period seems to be low. To answer the second question, we included 40 patients suffering from type I allergy to grass/rye pollen in a clinical study. Each of them had previously undergone specific IT with a grass pollen extract mixture and had terminated this therapy after 3-4 years practically free of symptoms during the grass pollen season. As the symptoms returned and increased from year to year after the end of IT, new therapeutic steps had to be considered. We investigated the efficacy of a short preseasonal injection treatment called "booster immunotherapy" (BIT). BIT was performed with two different injection-regimens, a low-dose schedule comprising six injections and a high-dose schedule with 11 injections, in both cases administered as a build-up regimen. In the next pollen season, 28/40 (70%) patients reported strong improvement or even complete remission of the allergy symptoms.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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C Ebner; D Kraft; H Ebner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergy Volume: 49 ISSN: 0105-4538 ISO Abbreviation: Allergy Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-06-30 Completed Date: 1994-06-30 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: DENMARK |
Other Details:
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Languages: eng Pagination: 38-42 Citation Subset: IM |
Affiliation:
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Institute of General and Experimental Pathology, University of Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Allergens* Asthma / immunology, therapy* Bronchitis / immunology, therapy* Confidence Intervals Conjunctivitis / immunology, therapy* Desensitization, Immunologic* Dose-Response Relationship, Drug Female Humans Immunization Schedule Immunization, Secondary* Immunoglobulin E / immunology Immunoglobulin G / immunology Injections Male Pollen* Questionnaires Recurrence Rhinitis, Allergic, Seasonal / immunology, therapy* Risk Factors Skin Tests Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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