| Bony metastases: assessing response to therapy with whole-body diffusion MRI. | |
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MedLine Citation:
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PMID: 22185786 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There are no universally accepted methods for assessing tumour response in skeletal sites with metastatic disease; response is assessed by a combination of imaging tests, serum and urine biochemical markers and symptoms assessments. Whole-body diffusion magnetic resonance imaging excels at bone marrow assessments at diagnosis and for therapy evaluations. It can potentially address unmet clinical and pharmaceutical needs for a reliable measure of tumour response. Signal intensity on high b-value images and apparent diffusion coefficient values can be related to underlying biophysical properties of skeletal metastases. Four patterns of change in response to therapy are described this review. Therapy response criteria need to be tested in prospective clinical studies that incorporate conventional measures of patient benefit. |
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Authors:
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A R Padhani; A Gogbashian |
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Publication Detail:
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Type: Journal Article Date: 2011-10-03 |
Journal Detail:
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Title: Cancer imaging : the official publication of the International Cancer Imaging Society Volume: 11 ISSN: 1470-7330 ISO Abbreviation: Cancer Imaging Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101172931 Medline TA: Cancer Imaging Country: England |
Other Details:
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Languages: eng Pagination: S129-45 Citation Subset: IM |
Affiliation:
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Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex, HA6 2RN, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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