Document Detail

Bones in coeliac disease: diagnosis and treatment.
MedLine Citation:
PMID:  15925849     Owner:  NLM     Status:  MEDLINE    
Coeliac disease predisposes to metabolic osteopathy. The entity of bone loss is higher in patients with malabsorption at diagnosis but it is also present in asymptomatic or poorly symptomatic patients, occurring in roughly half of them. Calcium malabsorption and the release of proinflammatory cytokines, activating osteoclasts, represent the main mechanisms responsible for bone derangement. In coeliacs, the presence of an increased fracture risk was recently questioned and its importance on clinical grounds was reconsidered, in view of the fact that gluten-free diet generally improves bone mass and, consequently, reduces fracture risk. However, gluten-free diet rarely normalizes bone mass and the co-administration of mineral active drugs may be useful in a subgroup of coeliacs.
Gino Roberto Corazza; Michele Di Stefano; Eduardo Mauriño; Julio C Bai
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical gastroenterology     Volume:  19     ISSN:  1521-6918     ISO Abbreviation:  Best Pract Res Clin Gastroenterol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-31     Completed Date:  2005-12-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101120605     Medline TA:  Best Pract Res Clin Gastroenterol     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-65     Citation Subset:  IM    
Department of Medicine, University of Pavia, IRCCS "S.Matteo" Hospital, P.le C. Golgi 19, 27100 Pavia, Italy.
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MeSH Terms
Bone Density
Bone Diseases, Metabolic / etiology*,  physiopathology
Bone and Bones / physiopathology
Celiac Disease / complications*,  physiopathology
Clinical Trials as Topic

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