Document Detail

Bone turnover markers in the management of postmenopausal osteoporosis.
MedLine Citation:
PMID:  19362543     Owner:  NLM     Status:  MEDLINE    
Osteoporosis is the most common cause of fragility fractures. Bone remodelling is essential for repairing damaged areas within bone to preserve bone strength and for assisting in mineral homeostases. In young adults, bone remodelling is usually balanced with approximately as much bone replaced as is removed during each remodelling cycle. However, when remodelling becomes accelerated in combination with an imbalance that favours bone resorption over formation, such as during menopause, precipitous losses in bone mass occur. Bone turnover markers (BTMs) measure the rate of bone remodelling allowing for a dynamic assessment of skeletal status and hold promise in identifying those at highest risk of rapid bone loss and subsequent fracture. Further, the use of BTMs to monitor individuals administered osteoporosis therapy is attractive as monitoring anti-fracture efficacy with bone mineral density has significant limitations. This review details remodelling biology, pre-analytical and analytical sources of variability for BTMs, describes the most commonly used resorption and formation markers, and offers some guidelines for their use and interpretation in the laboratory and the clinic.
Jacques P Brown; Caroline Albert; Bassam A Nassar; Jonathan D Adachi; David Cole; K Shawn Davison; Kent C Dooley; Andrew Don-Wauchope; Pierre Douville; David A Hanley; Sophie A Jamal; Robert Josse; Stephanie Kaiser; John Krahn; Richard Krause; Richard Kremer; Raymond Lepage; Elaine Letendre; Suzanne Morin; Daylily S Ooi; Alexandra Papaioaonnou; Louis-Georges Ste-Marie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-04-10
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-08-28     Revised Date:  2011-09-27    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-42     Citation Subset:  IM    
Université Laval, Québec, QC, Canada.
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MeSH Terms
Biological Markers / metabolism
Bone Remodeling / physiology*
Bone Resorption / metabolism,  physiopathology
Osteogenesis / physiology
Osteoporosis, Postmenopausal / metabolism*,  physiopathology,  therapy*
Reg. No./Substance:
0/Biological Markers
Comment In:
Clin Biochem. 2011 Sep;44(13):1033-4   [PMID:  21784064 ]

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