| Bone tissue response to implant surfaces functionalized with phosphate-containing polymers. | |
| | |
MedLine Citation:
|
PMID: 23039076 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: Inorganic polyphosphates are said to stimulate the activity of osteoblast-like cells in vitro. The purpose of this study was to evaluate in vivo bone regeneration around implants treated with polyphosphoric acid (PPA) and phosphorylated pullulan (PPL). MATERIAL AND METHODS: Two types of implants with different surface roughness (R1: Sa ≈ 0.23 μm; R2: Sa ≈ 1.35 μm) were treated with three solutions (distilled water, 10%wt PPA, or 10%wt PPL) prior to implantation in both tibia of twelve female white rabbits. Each animal received six implants randomly positioned according to their surface roughness and treatment: R1 + water; R1 + PPA; R1 + PPL; R2 + water; R2 + PPA; R2 + PPL. Animals were sacrificed after 1 or 4 weeks, and samples were prepared for histological and histomorphometrical analysis. Bone regeneration areas were evaluated for bone-to-implant contact (BIC) and bone fraction (BF) in areas 100 and 500 μm remote from the implant surface. Data were statistically analyzed by means of Friedman and Wilcoxon matched-pair tests (P < 0.05). RESULTS: After 1 week, bone tissue was rarely formed in the regeneration areas. After 4 weeks, implants treated with PPA presented higher ratios of BIC (R1 = 52.3 ± 13.1; R2 = 54.6 ± 11.0) than the ones treated with water (R1 = 24.1 ± 15.1; R2 = 32.4 ± 13.0). On the other hand, around the implant surface (100 μm), PPL-treated implants induced higher BF (R1 = 78.3 ± 34.1; R2 = 71.2 ± 21.8) as compared with the water-treated ones (R1 = 46.1 ± 22.0; R2 = 49.6 ± 21.0). At 500 μm, however, no statistically significant differences in BF were found among the groups evaluated (P > 0.05). Surface roughness influenced neither BIC nor BF. CONCLUSIONS: Implant surface treatment with phosphate-containing polymers may positively influence osseointegration. |
| | |
Authors:
|
Marcio Vivan Cardoso; Amol Chaudhari; Yasuhiro Yoshida; Bart Van Meerbeek; Ignace Naert; Joke Duyck |
Related Documents
:
|
21625376 - Comparison of tcp and tcp/ha hybrid scaffolds for osteoconductive activity. 20737936 - Applied anatomic site study of palatal anchorage implants using cone beam computed tomo... 3429176 - Quantitative computed tomography scanning for measurement of bone and bone marrow fat c... 17229586 - Accuracy of high-resolution peripheral quantitative computed tomography for measurement... 21295306 - Efficient computational method for assessing the effects of implant positioning in ceme... 3475356 - An evaluation of a glass ionomer luting agent: bacterial leakage. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-8 |
Journal Detail:
|
Title: Clinical oral implants research Volume: - ISSN: 1600-0501 ISO Abbreviation: Clin Oral Implants Res Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105713 Medline TA: Clin Oral Implants Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 John Wiley & Sons A/S. |
Affiliation:
|
Leuven BIOMAT Research Cluster, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University of Leuven, Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Premedication for neonatal intubation in Australia and New Zealand: A survey of current practice.
Next Document: Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite ...