Document Detail


Bone tissue composition varies across anatomic sites in the proximal femur and the iliac crest.
MedLine Citation:
PMID:  22034199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The extent to which bone tissue composition varies across anatomic sites in normal or pathologic tissue is largely unknown, although pathologic changes in bone tissue composition are typically assumed to occur throughout the skeleton. Our objective was to compare the composition of normal cortical and trabecular bone tissue across multiple anatomic sites. The composition of cadaveric bone tissue from three anatomic sites was analyzed using Fourier transform infrared imaging: iliac crest (IC), greater trochanter (GT), and subtrochanteric femur (ST). The mean mineral:matrix ratio was 20% greater in the subtrochanteric cortex than in the cortices of the iliac crest (p = 0.004) and the greater trochanter (p = 0.02). There were also trends toward 30% narrower crystallinity distributions in the subtrochanteric cortex than in the greater trochanter (p = 0.10) and 30% wider crystallinity distributions in the subtrochanteric trabeculae than in the greater trochanter (p = 0.054) and the iliac crest (p = 0.11). Thus, the average cortical tissue mineral content and the widths of the distributions of cortical crystal size/perfection differ at the subtrochanteric femur relative to the greater trochanter and the iliac crest. In particular, the cortex of the iliac crest has lower mineral content relative to that of the subtrochanteric femur and may have limited utility as a surrogate for subtrochanteric bone.
Authors:
Eve Donnelly; Dennis S Meredith; Joseph T Nguyen; Adele L Boskey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-27
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  30     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-05-01     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  700-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Orthopaedic Research Society.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Female
Femur / anatomy & histology,  chemistry*
Humans
Ilium / anatomy & histology,  chemistry*
Male
Middle Aged
Spectroscopy, Fourier Transform Infrared
Grant Support
ID/Acronym/Agency:
F32 AR056148-03/AR/NIAMS NIH HHS; P30 AR046121/AR/NIAMS NIH HHS; P30 AR046121/AR/NIAMS NIH HHS; P30 AR046121-10/AR/NIAMS NIH HHS; R01 AR041325/AR/NIAMS NIH HHS; R01 AR041325-20/AR/NIAMS NIH HHS; R01 AR043125/AR/NIAMS NIH HHS; UL1-RR024996/RR/NCRR NIH HHS
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