Document Detail

Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content.
MedLine Citation:
PMID:  9848500     Owner:  NLM     Status:  MEDLINE    
Our previous studies showed that a soy-protein diet prevents ovariectomy-induced bone loss. The purpose of this study was to determine whether isoflavones in soy protein are responsible for this bone-protective effect. Forty-eight 95-d-old Sprague-Dawley rats were divided into 4 groups: sham-operated fed a casein-based diet (SHAM), ovariectomized fed a casein-based diet (OVX+CASEIN), ovariectomized fed soy protein with normal isoflavone content (OVX+SOY), and ovariectomized fed soy protein with reduced isoflavone content (OVX+SOY-). The OVX+SOY group had significantly greater femoral bone density (in g/cm3 bone vol) than the OVX+CASEIN group, whereas OVX+SOY- was similar to OVX+CASEIN (mean +/- SD; SHAM, 1.522 +/- 0.041; OVX+CASEIN, 1.449 +/- 0.044; OVX+SOY, 1.497 +/- 0.030; OVX+SOY-, 1.452 +/- 0.030). Ovariectomy resulted in greater bone turnover as indicated by higher serum alkaline phosphatase activity, serum insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations, and urinary hydroxyproline. These increases were not affected by soy with either normal or reduced isoflavone content. Similarly, histomorphometry revealed a greater bone formation rate with ovariectomy, and this was not altered by the soy diets. The findings of this study suggest that isoflavones in soy protein are responsible for its bone-sparing effects. Further studies to evaluate the mechanism of action of isoflavones on bone are warranted.
B H Arjmandi; R Birnbaum; N V Goyal; M J Getlinger; S Juma; L Alekel; C M Hasler; M L Drum; B W Hollis; S C Kukreja
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  68     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-06     Completed Date:  1999-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1364S-1368S     Citation Subset:  AIM; IM    
Department of Nutritional Sciences, Oklahoma State University, Stillwater 74078-6141, USA.
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MeSH Terms
Bone Density / drug effects*
Caseins / administration & dosage,  pharmacology
Dose-Response Relationship, Drug
Estrogens / deficiency*
Isoflavones / administration & dosage,  therapeutic use*
Osteoporosis / etiology,  prevention & control*
Rats, Sprague-Dawley
Soybean Proteins / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Caseins; 0/Estrogens; 0/Isoflavones; 0/Soybean Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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