Document Detail


Bone and skeletal muscle: neighbors with close ties.
MedLine Citation:
PMID:  23630111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The musculoskeletal system evolved in mammals to perform diverse functions that include locomotion, facilitating breathing, protecting internal organs, and coordinating global energy expenditure. Bone and skeletal muscles involved with locomotion are both derived from somitic mesoderm and accumulate peak tissue mass synchronously, according to genetic information and environmental stimuli. Aging results in the progressive and parallel loss of bone (osteopenia) and skeletal muscle (sarcopenia) with profound consequences for quality of life. Age-associated sarcopenia results in reduced endurance, poor balance, and reduced mobility that predispose elderly individuals to falls, which more frequently result in fracture because of concomitant osteoporosis. Thus, a better understanding of the mechanisms underlying the parallel development and involution of these tissues is critical to developing new and more effective means to combat osteoporosis and sarcopenia in our increasingly aged population. This perspective highlights recent advances in our understanding of mechanisms coupling bone and skeletal muscle mass, and identify critical areas where further work is needed.
Authors:
Douglas J DiGirolamo; Douglas P Kiel; Karyn A Esser
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  28     ISSN:  1523-4681     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-19     Completed Date:  2013-11-04     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1509-18     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Society for Bone and Mineral Research.
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MeSH Terms
Descriptor/Qualifier:
Accidental Falls*
Aging*
Animals
Bone Diseases, Metabolic / physiopathology*
Bone and Bones / physiopathology*
Humans
Muscle, Skeletal / physiopathology*
Postural Balance*
Sarcopenia / physiopathology*
Grant Support
ID/Acronym/Agency:
R01 AR061939/AR/NIAMS NIH HHS; R01 AR062074/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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