| BONE REGENERATION: STEM CELL THERAPIES AND CLINICAL STUDIES IN ORTHOPAEDICS AND TRAUMATOLOGY. | |
| | |
MedLine Citation:
|
PMID: 21251219 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Regenerative medicine seeks to repair or replace damaged tissues or organs, with the goal to fully restore structure and function without the formation of scar tissue. Cell based therapies are promising new therapeutic approaches in regenerative medicine. By using mesenchymal stem cells (MSC), good results have been reported for bone engineering in a number of clinical studies, most of them investigator initiated trials with limited scope with respect to controls and outcome. With the implementation of a new regulatory framework for advanced therapeutic medicinal products (ATMP), the stage is set to improve both the characterization of the cells and combination products, and pave the way for improved controlled and well designed clinical trials. The incorporation of more personalized medicine approaches, including the use of biomarkers to identify the proper patients and the responders to treatment, will be contributing to progress in the field. Both translational and clinical research will move the boundaries in the field of regenerative medicine, and a coordinated effort will provide the clinical breakthroughs, particularly in the many applications of bone engineering. |
| | |
Authors:
|
Enrique Gómez-Barrena; Philippe Rosset; Ingo Müller; Rosaria Giordano; Carmen Bunu; Pierre Layrolle; Yrjö T Konttinen; Frank P Luyten |
Related Documents
:
|
21339099 - How to distinguish between 'business as usual' and 'significant business disruptions' a... 12497679 - Non-evidence-based use of rho(d) immune globulin for threatened abortion by family prac... 21456499 - Sustainable leadership in a thai healthcare services provider. 6950599 - Preliminary report: a clinical appraisal of the mcgoldrick rotational vacuum extractor. 18086069 - Accidental dural puncture and post dural puncture headache in obstetric anaesthesia: pr... 19546769 - Retention of chairs in obstetrics and gynecology: a comparison with other clinical depa... 12180359 - If not evidence, then what? or does medicine really need a base? 21743849 - Eczema. 20468989 - The role of housing in management of chronic disease. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-20 |
Journal Detail:
|
Title: Journal of cellular and molecular medicine Volume: - ISSN: 1582-4934 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101083777 Medline TA: J Cell Mol Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
2011. |
Affiliation:
|
Orthopaedic Surgery Service, Hospital Universitario "La Paz", Autónoma University of Madrid, Madrid, Spain Service of Orthopaedic Surgery, Centre Hospitalier Universitaire de Tours, University of Tours, Tours, France Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Germany Cell Factory "Franco Calori", Center of Transfusion Medicine, Cellular Therapy and Cryobiology, Fondazione IRCCS "Ca' Granda" Ospedale Maggiore Policlinico, Milan, Italy Victor Babes University of Medicine and Pharmacy Timisoara, Romania Inserm U957, LPRO, Faculty of Medicine, University of Nantes, Nantes, France Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland ORTON Orthopaedic Hospital, ORTON Foundation, Helsinki, Finland COXA Hospital for Joint Replacement, Tampere, Finland Department of Musculoskeletal Sciences, Prometheus Division, KULeuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Calcitonin Receptor-Mediated CFTR Activation in Human Intestinal Epithelial Cells.
Next Document: Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells.