Document Detail

Bone regenerated via rhPDGF-bB and a deproteinized bovine bone matrix: backscattered electron microscopic element analysis.
MedLine Citation:
PMID:  18092448     Owner:  NLM     Status:  MEDLINE    
This study used backscattered electron microscopy (BSE-SEM) to analyze specimens in which bone was augmented both horizontally and vertically with a xenograft scaffold and recombinant human platelet-derived growth factor (rhPDGF-BB), with or without a resorbable collagen membrane. The study objective was to compare percentage weight and volume calcium-phosphorus ratios of regenerated bone and native bone and the nature of the bony contact with two different implant surfaces. Examination of the nature of the mineralized tissues by BSE-SEM provides an understanding of the composition and element ratio of bone regenerated from nonautogenous grafts. The data collected demonstrated no statistically significant difference between regenerated bone and native bone in the two tested groups. Our observations suggest that bone regenerated via nonautogenous grafts displays composition, structure, and physical properties very similar to those of native bone. Similarly, no significant differences were observed at the bone-implant interface between bone regenerated proximal to oxidized versus machined implants.
Isabella Rocchietta; Claudia Dellavia; Myron Nevins; Massimo Simion
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of periodontics & restorative dentistry     Volume:  27     ISSN:  0198-7569     ISO Abbreviation:  Int J Periodontics Restorative Dent     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200894     Medline TA:  Int J Periodontics Restorative Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-45     Citation Subset:  D    
Department of Periodontology, School of Dentistry, University of Milan, Italy.
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MeSH Terms
Alveolar Ridge Augmentation / methods*
Bone Matrix / transplantation*
Bone Regeneration / drug effects*
Calcium / analysis
Drug Carriers
Electron Probe Microanalysis
Guided Tissue Regeneration, Periodontal / methods
Phosphorus / analysis
Platelet-Derived Growth Factor / administration & dosage,  pharmacology*
Recombinant Proteins / administration & dosage,  pharmacology
Reg. No./Substance:
0/Drug Carriers; 0/Platelet-Derived Growth Factor; 0/Recombinant Proteins; 0/platelet-derived growth factor BB; 7440-70-2/Calcium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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