Document Detail


Bone properties in patients with acromegaly: quantitative ultrasound of the heel.
MedLine Citation:
PMID:  17543559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Growth hormone (GH) deficiency and acromegaly serve as good models for investigating the effects of GH on bone remodeling. However, the results from various studies are rather conflicting. The aim of our study was to estimate the potential role of gender, disease activity, and duration on both calcaneus quantitative ultrasound (QUS) parameters and bone turnover markers in patients with acromegaly. Thirty-six acromegalic patients (17 men, 19 women) and 3 age- and gender-adjusted controls for every patient were included in the study. The disease was active in 22 patients, and was considered cured in 14 of them. In each subject, QUS of the heel and parameters of bone turnover (bone alkaline phosphatase, beta-crosslaps, and osteocalcin) were measured. The results demonstrated lower QUS values in acromegalic patients compared with the controls. When stratified by gender, the differences in QUS parameters were significant in men, but not in women. Male patients with active disease had significantly lower QUS values than those in remission. Such differences were not observed among women. Multiple regression model indicated strong association between disease activity and the QUS parameters. The group of patients with active disease had a higher level of serum beta-crosslaps, whereas osteocalcin concentration was significantly increased only in male patients with active disease. The results of our study suggest significantly lower QUS values and increased bone turnover in male patients with active acromegaly. The disease activity is the strongest predictor of the QUS parameters in acromegalic patients.
Authors:
Darko Kastelan; Tina Dusek; Ivana Kraljevic; Ozren Polasek; Zdravko Perkovic; Iva Kardum; Zlatko Giljevic; Jozo Jelcic; Izet Aganovic; Mirko Korsic
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Publication Detail:
Type:  Journal Article     Date:  2007-06-01
Journal Detail:
Title:  Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry     Volume:  10     ISSN:  1094-6950     ISO Abbreviation:  J Clin Densitom     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808212     Medline TA:  J Clin Densitom     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
Affiliation:
Divison of Endocrinology, Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia.
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MeSH Terms
Descriptor/Qualifier:
Acromegaly / metabolism*,  ultrasonography*
Adult
Alkaline Phosphatase / metabolism
Biological Markers / metabolism
Bone Density*
Bone Remodeling / physiology*
Calcaneus / ultrasonography*
Case-Control Studies
Collagen / metabolism
Female
Humans
Male
Middle Aged
Osteocalcin / metabolism
Peptide Fragments / metabolism
Severity of Illness Index
Sex Factors
Time Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; 104982-03-8/Osteocalcin; 9007-34-5/Collagen; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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