Document Detail


Bone physiology during pregnancy and lactation in young macaques.
MedLine Citation:
PMID:  10491226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used a nonhuman primate model (Macaca nemestrina) of adolescent human pregnancy to characterize bone remodeling at midpregnancy and at weaning and the associated changes in bone mass. In this longitudinal study, 125 nulliparous females were followed through pregnancy, 6 months of lactation, and 3 months postweaning; 13 nonpregnant females served as controls. Between early pregnancy and midpregnancy, the whole body bone mineral increased. There was no significant change between midpregnancy and parturition. Between parturition and 3 months lactation, the animals lost 3.0% of their bone mineral (p < 0.01), which was regained by 3 months after weaning. The vertebral bone mineral apparent density decreased during pregnancy and 6 months of lactation, followed by an increase during the 3 months after weaning. Calcium, phosphate, 25-hydroxyvitamin D, and osteocalcin increased significantly from midpregnancy to weaning whereas 1,25-dihydroxyvitamin D values showed significant decreases. Histomorphometric measurements from bone biopsies showed significant increases in most parameters of bone formation between pregnancy and weaning. These results are consistent with the hypothesis that at midpregnancy bone formation is decreased and cancellous bone resorption may have increased. During lactation, losses occur in both cortical and cancellous bone, partially depleting the maternal reservoir of calcium, but a subsequent increase in bone formation enables restoration of bone mineral after weaning to values similar to those in the control group.
Authors:
S M Ott; E W Lipkin; L Newell-Morris
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  14     ISSN:  0884-0431     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-10     Completed Date:  1999-11-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1779-88     Citation Subset:  IM    
Affiliation:
Department of Medicine and Anthropology, University of Washington, Seattle, Washington 98195-6426, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Animals
Bone Density / physiology*
Bone Remodeling / physiology*
Calcium / physiology
Female
Humans
Lactation / physiology*
Macaca nemestrina
Models, Biological
Parathyroid Glands / physiology
Pregnancy
Pregnancy, Animal / physiology*
Spine / physiology
Grant Support
ID/Acronym/Agency:
P30 DK35816/DK/NIDDK NIH HHS; R01 AR40813-01/AR/NIAMS NIH HHS; RR00166/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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