| Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering. | |
| | |
MedLine Citation:
|
PMID: 23344924 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In this study, a silica xerogel-chitosan hybrid is utilized as a coating material to incorporate bone morphogenic protein-2 (BMP-2) on a porous hydroxyapatite (HA) scaffold for bone tissue engineering. BMP-2 is known as a therapeutic agent for improving bone regeneration and repair. Silica xerogel-chitosan hybrids have been used for the delivery of a growth factor as well as osteoconductive coatings. The biological properties of the hybrid coating incorporated with BMP-2 were evaluated in terms of the BMP-2 release behavior, osteoblastic cellular responses and in vivo performance. BMP-2 was continuously released from the hybrid coating layer on the porous HA scaffold for up to 6 weeks. The hybrid coating containing BMP-2 showed significantly enhanced osteoblastic cell responses in comparison with the hybrid coating and HA substrate. Consequently, new bone formation was significantly increased within the hybrid coating containing BMP-2. These results reveal that the hybrid coating containing BMP-2 has the potential to be used as a bone implant, whose osteogenic properties are promoted by the release of BMP-2 in a controlled manner for a prolonged period of time. |
| | |
Authors:
|
Shin-Hee Jun; Eun-Jung Lee; Tae-Sik Jang; Hyoun-Ee Kim; Jun-Hyeog Jang; Young-Hag Koh |
Related Documents
:
|
23241764 - Brown class iii maxillectomy defects reconstruction with prefabricated titanium mesh an... 23053744 - Behaviour of mesenchymal stem cells from bone marrow of untreated advanced breast and l... 21751424 - The effects of glucocorticoid on microarchitecture, collagen, mineral and mechanical pr... 23124894 - Apoptosis of the reduced enamel epithelium and its implications for bone resorption dur... 1458624 - Results of full-thickness laryngotracheal wall reconstruction: a survey of the literature. 6368564 - Intramedullary rodding with bailey-dubow extensible rods in osteogenesis imperfecta. an... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
|
Title: Journal of materials science. Materials in medicine Volume: - ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
WCU Hybrid Materials Program, Department of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after str...
Next Document: The historical development of mechanochemistry.