Document Detail


Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Maureen Owen revisited.
MedLine Citation:
PMID:  7641468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In postnatal mammals, there are persistent molecular signals and responding cells in bone to initiate osteogenesis and repair in response to trauma. The responding osteogenic precursor cells are of 2 categories: determined and inducible. The latter can be induced by demineralized bone matrix to form bone. Demineralized bone matrix consists of extracellular matrix and tightly associated bone morphogenetic proteins. The genes for bone morphogenetic proteins have been cloned, the recombinant proteins have been expressed, and currently their mechanism of action is being explored. Bone morphogenetic proteins are pleiotropic initiators of inducible osteogenic precursor cells. Bone morphogenetic proteins govern the 3 key steps in the osteogenic cascade: chemotaxis, mitosis, and differentiation. The receptors for bone morphogenetic proteins have been cloned and expressed and consist of 2 classes, Types I and II, that are membrane bound serine/threonine protein kinases. Bone morphogenetic proteins bind to extracellular matrix and their collaborative action on osteogenic cells culminates in the terminal differentiation of the osteoblast-osteocyte continuum. Bone morphogenetic proteins are currently on the threshold for clinical applications.
Authors:
A H Reddi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Orthopaedic Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Cells*
Bone Morphogenetic Proteins
Cell Differentiation
Extracellular Matrix / metabolism
Growth Substances / physiology*
Humans
Proteins / physiology*
Stem Cells / physiology*
Stromal Cells / physiology
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Growth Substances; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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