Document Detail


Bone morphogenetic protein-9 (BMP-9) induces epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma cells.
MedLine Citation:
PMID:  23281849     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
80 - 90% of primary liver cancer cases originate from hepatocellular carcinoma (HCC), which has been regarded as the fifth most common cancer and the third most fatal reason responsible for cancer-related death in the world.(1) Current therapeutic options including surgical resection, liver transplantation and chemoembolization are only used at early stages of HCC with limited efficacy.(2) Cancer recurrence occurs in around 50% of the patients.(3,4) Despite extensive scientific efforts, the prognosis of HCC is nowadays still poor since HCC is inclined to tumor invasiveness and formation of intra- and extra-hepatic metastases.
Authors:
Qi Li; Xing Gu; Honglei Weng; Shahrouz Ghafoory; Yan Liu; Teng Feng; Johanna Dzieran; Li Li; Iryna Iikavets; Marianna Kruithof- de Julio; Stefan Munker; Alexander Marx; Albrecht Piiper; Eduardo Augusto Alonso; Norbert Gretz; Chunfang Gao; Stefan Wölfl; Steven Dooley; Katja Breitkopf-Heinlein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Japanese Cancer Association.
Affiliation:
Department of Medicine II, Section Molecular Hepatology - Alcohol Associated Diseases, Medical Faculty Mannheim at Heidelberg University, Mannheim, Germany; Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Beijing, China.
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