Document Detail


Bone mineralization in young patients with type 1 diabetes mellitus and screening-identified evidence of celiac disease.
MedLine Citation:
PMID:  17939041     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aims of this study were to evaluate bone mineral density (BMD) and bone turnover markers in patients with type 1 diabetes and screening-identified evidence of celiac disease, i.e., celiac autoimmunity. We screened 50 consecutive type 1 diabetic patients for IgA antitissue transglutaminase to identify those with celiac autoimmunity. Eight seropositive patients were identified on this screening, and 12 patients matched for gender and age range were selected as a control group from among the type 1 diabetic patients without celiac autoimmunity. Patients and controls underwent dual-energy X-ray absorptiometry (DEXA) for measurement of bone mineral status and had their blood levels of osteocalcin, carboxy-terminal telopeptide of type I collagen (CTX), calcium, and phosphorus determined. BMD was further adjusted for height, weight, and pubertal stage. Radiographic and blood markers of bone mineralization were compared between patients and controls. BMD (Z-score) at the lumbar spine was -1.44 +/- 0.5 SD for patients and 0.04 +/- 0.2 SD for controls (P = 0.02). Bone mineral content was 37.9 +/- 4.5 g for patients and 49.4 +/- 2.6 g for controls (P = 0.049). Adjusted BMD was -0.62 +/- 0.5 SD for patients and 0.81 +/- 0.09 SD for controls (P = 0.04). After adjustment, four patients and none of the controls presented BMD < -1 SD (P = 0.01). Osteocalcin, CTX, calcium, and phosphorus blood levels were not significantly different between patients and controls. Celiac autoimmunity is associated with reduced bone mineralization in type 1 diabetic patients. The pathophysiological mechanisms and clinical relevance of this finding remain to be further investigated.
Authors:
Daniel R Diniz-Santos; Flávia Brandão; Luis Adan; Agnaluce Moreira; Eliézer J Vicente; Luciana R Silva
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-16
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-10     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1240-5     Citation Subset:  AIM; IM    
Affiliation:
Division of Pediatric Gastroenterology and Hepatology, Hosannah de Oliveira Pediatric Center, Federal University of Bahia, Salvador, Bahia, Brazil. dinizsantosdr@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adolescent
Bone Density*
Case-Control Studies
Celiac Disease / immunology*,  physiopathology*
Diabetes Mellitus, Type 1 / immunology*,  physiopathology*
Female
Humans
Immunoglobulin A / immunology
Male
Statistics, Nonparametric
Transglutaminases / immunology
Chemical
Reg. No./Substance:
0/Immunoglobulin A; EC 2.3.2.13/Transglutaminases; EC 2.3.2.13/transglutaminase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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