Document Detail

Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour.
MedLine Citation:
PMID:  14985884     Owner:  NLM     Status:  MEDLINE    
Prolonged maternal magnesium sulphate infusion therapy for tocolysis of premature labour may result in secondary fetal hypermagnesaemia, which has been associated with bony abnormalities in the newborn. We report on four infants, members of two twin pregnancies, who were exposed to prolonged fetal hypermagnesaemia. Three of the infants, all appropriate for gestational age, showed abnormal radiological findings consisting of abnormal mineralisation of long-bone metaphyses owing to fetal hypermagnesaemia. The fourth infant, who was growth retarded, had normal bones. Intrauterine growth restriction appears to be protective against magnesium sulphate-induced abnormal bone mineralisation in the newborn.
Shadi N Malaeb; Adriana I Rassi; Maurice C Haddad; Muhieddine A Seoud; Khalid A Yunis
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2004-02-18
Journal Detail:
Title:  Pediatric radiology     Volume:  34     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-15     Completed Date:  2004-09-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  384-6     Citation Subset:  IM    
Department of Pediatrics, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*,  radiography
Bone Density / drug effects*
Bone and Bones / abnormalities*,  radiography
Infant, Newborn
Magnesium Sulfate / adverse effects*,  therapeutic use
Tocolysis / adverse effects*
Reg. No./Substance:
7487-88-9/Magnesium Sulfate

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