| Bone mineral density with lamotrigine monotherapy for epilepsy. | |
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MedLine Citation:
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PMID: 17903668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone mass, largely accumulated during childhood and adolescence, may be reduced in patients with epilepsy as a result of epilepsy or of antiepileptic medications. Enzyme-inducing medications increase bone-turnover markers, although the effects of newer medications on bone accrual are not well-defined. Total z-score bone mineral density was measured in 13 children, treated with lamotrigine monotherapy, who had never been exposed to other medications, and compared with 36 control subjects and 40 patients exposed to polytherapy. All patients were normally ambulatory and had similar physical activity and calcium intake. The z-scores of bone mineral density for lamotrigine and control subjects were similar (0.52 +/- 0.76 versus 0.49 +/- 0.7) and higher than those receiving polytherapy for 1-5 years (0.14 +/- 0.8, P = 0.12) and >or=6 years (-0.27 +/- 01.15, P < 0.003). Increasing duration of epilepsy was associated with lower bone density for 1-5 years of polytherapy (Spearman's correlation coefficient r = +0.006, P = 0.74) and >or=6 years of polytherapy (Spearman's correlation coefficient r = +0.12, P = 0.13), but not for lamotrigine. These data suggest that lamotrigine may not interfere with bone accrual. |
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Authors:
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Raj D Sheth; Bruce P Hermann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric neurology Volume: 37 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2007-11-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 250-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Wisconsin at Madison, Madison, Wisconsin 53792-5132, USA. sheth@neurology.wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anticonvulsants / administration & dosage, adverse effects*, therapeutic use Bone Density / drug effects* Calcium / administration & dosage Child Cross-Sectional Studies Diet Drug Administration Schedule Drug Therapy, Combination Epilepsy / drug therapy*, metabolism*, physiopathology Female Growth Humans Male Motor Activity Triazines / administration & dosage, adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Triazines; 7440-70-2/Calcium; 84057-84-1/lamotrigine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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