Document Detail

Bone mineral density and urolithiasis interaction in rheumatoid arthritis.
MedLine Citation:
PMID:  15108069     Owner:  NLM     Status:  MEDLINE    
Rheumatoid arthritis (RA) is a systemic inflammatory disease with extraarticular manifestations involving many organs. Both urinary stone formation and bone mineral density (BMD) can be affected by calcium (Ca) metabolism changes in RA. We aimed, in our study, to investigate the incidence of urolithiasis in adult RA patients and to identify the BMD characteristics of stone-forming RA patients. Seventy-nine RA patients and 35 control subjects participated in our study. None had a known renal disease, except for urolithiasis. Complete blood count (CBC), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and C-reactive protein (CRP) were recorded. Twenty-four-hour urinalysis, as well as plain X-ray, ultrasound imaging, and BMD measurements with dual-energy X-ray absorptiometry (DEXA) were performed. T scores more than 1 SD below the mean value were accepted as low BMD. There was no statistically significant difference between urinary stone incidence in RA patients and controls. There was a significant difference between BMD values in RA patients with and without urinary stone disease. The low T scores of stone-forming RA patients may be explained by the additive effect of two coexisting diseases, both shown to be related to low bone mass. From another point of view, both BMD loss and urolithiasis can be consequences of altered Ca metabolism in RA. So we suggest that RA patients with urolithiasis should be evaluated for BMD, and that RA patients with low BMD be evaluated for urolithiasis.
Nurgül Arinci Incel; Nazmi Incel; Bariş Nacir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bone and mineral metabolism     Volume:  22     ISSN:  0914-8779     ISO Abbreviation:  J. Bone Miner. Metab.     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-26     Completed Date:  2005-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9436705     Medline TA:  J Bone Miner Metab     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  260-3     Citation Subset:  IM    
Department of Physical Medicine and Rehabilitation, Mersin University Faculty of Medicine, 33079 Mersin, Turkey.
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MeSH Terms
Absorptiometry, Photon
Arthritis, Rheumatoid / complications*,  pathology,  physiopathology*
Bone Density / physiology*
Middle Aged
Risk Factors
Urinary Calculi / complications*,  pathology

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