Document Detail

Bone mineral density in women with essential hypertension.
MedLine Citation:
PMID:  11465657     Owner:  NLM     Status:  MEDLINE    
Recent studies have reported the abnormalities in calcium metabolism at the systemic level in human hypertension as well as in experimental hypertension. Because bone is the largest store of calcium in the body, the bone calcium content and mineralization may represent the entire calcium balance. The present study was undertaken to investigate the bone mineral density (BMD) in women with essential hypertension by means of the dual-energy X-ray absorptiometric (DXA) method. The DXA analysis showed a significant decrease in BMD in female hypertensive subjects compared with normotensive subjects. In addition, the BMD was inversely correlated with systolic blood pressure in women. The 24-h urinary calcium excretion was significantly greater in female hypertensive subjects than in female normotensive subjects. Furthermore, the greater the urinary calcium excretion, the lower the BMD in women. The values of serum total calcium, total magnesium, ionized calcium, and 1, 25(OH)2 vitamin D were not different between hypertensive and normotensive subjects. The results of the present study demonstrated that DXA provided an index of whole calcium balance, and suggest that high blood pressure might be associated with reduced BMD in female hypertension.
K Tsuda; I Nishio; Y Masuyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  14     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-23     Completed Date:  2001-12-07     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  704-7     Citation Subset:  IM    
Department of Medicine, Wakayama Medical University, Japan.
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MeSH Terms
Absorptiometry, Photon
Blood Pressure
Bone Density*
Calcium / urine
Hypertension / diagnosis*,  urine
Lumbar Vertebrae
Middle Aged
Reg. No./Substance:
Comment In:
Am J Hypertens. 2002 May;15(5):475; author reply 475-6   [PMID:  12022253 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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