| Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls. | |
| | |
MedLine Citation:
|
PMID: 10666165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To examine bone mineral density (BMD) frequency of osteoporosis and reduced bone mass in systemic lupus erythematosus (SLE), and compare the data of the SLE patients with matched rheumatoid arthritis (RA) patients and healthy controls. Secondly, to study possible correlations between BMD, demographic and disease variables in the SLE patients. METHODS: Measures of BMD assessed by dual energy x ray absorptiometry were obtained from 75 SLE patients aged </= 70 years, 75 RA patients matched for age, sex and disease duration, and from 75 healthy controls matched for age, sex and geographical area. Disease activity and accumulated organ damage were assessed in the SLE patients. RESULTS: The SLE patients had significantly lower BMD values at lumbar spine L2-L4 and hip, and higher frequency of osteoporosis at all sites of measurement compared with matched healthy controls. The matched SLE and RA patients had similar BMD, prevalence of osteoporosis and reduced bone mass. In the SLE patients BMD was more strongly correlated with accumulated organ damage than with markers of disease activity or duration. In multivariate analyses BMD was at all sites predicted by age and body mass, at lumbar spine also by the current corticosteroid dose. CONCLUSION: The study showed reduced BMD in patients with SLE compared with matched healthy controls. Premenopausal women taking corticosteroids were especially affected. Furthermore, the BMD of matched SLE and RA patients was reduced to a similar extent. |
| | |
Authors:
|
I M Gilboe; T K Kvien; G Haugeberg; G Husby |
Related Documents
:
|
19946035 - Fcgr3b copy number variation is not associated with lupus nephritis in a chinese popula... 14593495 - Clinical and genetic risk factors of herpes zoster in patients with systemic lupus eryt... 2146135 - Detection of autoantibodies to sm antigen in systemic lupus erythematosus by immunodiff... 7323785 - Dermatoglyphics and systemic lupus erythematosus. 3823795 - Brucella arthritis. 12694345 - Why do we need a statin trial in hemodialysis patients? |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of the rheumatic diseases Volume: 59 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2000 Feb |
Date Detail:
|
Created Date: 2000-03-30 Completed Date: 2000-03-30 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 110-5 Citation Subset: IM |
Affiliation:
|
Oslo City Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorptiometry, Photon Adult Aged Arthritis, Rheumatoid / complications, physiopathology* Bone Density* Case-Control Studies Female Follow-Up Studies Glucocorticoids / adverse effects Humans Lupus Erythematosus, Systemic / complications, physiopathology* Male Middle Aged Multivariate Analysis Osteoporosis / etiology, physiopathology* Premenopause / physiology Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hormone replacement therapy and patterns of osteoarthritis: baseline data from the Ulm Osteoarthriti...
Next Document: Racial group, socioeconomic status, and the development of persistent proteinuria in systemic lupus ...