Document Detail


Bone mineral density in premenopausal women with systemic lupus erythematosus.
MedLine Citation:
PMID:  14677178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study bone mineral density (BMD) in premenopausal women with systemic lupus erythematosus (SLE) and to evaluate the influence of disease activity and use of corticosteroids. METHODS: A cross-sectional study on BMD of 118 premenopausal women with SLE. Patients were divided into 2 groups, 74 who had been treated with corticosteroids and 44 who had not. BMD at lumbar spine, femoral neck, and trochanter was measured. RESULTS: BMD in patients without and with corticosteroid treatment was 1.13 +/- 0.13 vs 1.05 +/- 0.14 g/cm2 (p = 0.005) at lumbar spine, 0.92 +/- 0.12 vs 0.86 +/- 0.12 g/cm2 (p = 0.005) at femoral neck, and 0.78 +/- 0.13 vs 0.72 +/- 0.12 g/cm2 (p = 0.014) at trochanter, respectively. Stepwise multilinear regression analysis showed that corticosteroid exposure was independently associated with decreased BMD in the corticosteroid treated patients (r2 = 7% for lumbar and 6.6% for trochanter model). No significant difference in BMD in corticosteroid treated patients appeared when they were subgrouped according to whether they were taking calcium supplements. Prevalence of osteoporosis at lumbar spine in corticosteroid treated patients was 1.4%, and was lower than reported for age and sex matched Caucasians. CONCLUSION: BMD measurements were significantly lower in premenopausal SLE patients who had had corticosteroid treatment than those who had not. There was a negative correlation between BMD and corticosteroid therapy, but not disease activity. Prevalence of osteoporosis, based on lumbar spine BMD, was lower than that reported in Caucasians.
Authors:
Somchai Uaratanawong; Utis Deesomchoke; Somrat Lertmaharit; Somsri Uaratanawong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  30     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-01-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  2365-8     Citation Subset:  IM    
Affiliation:
Rheumatology Unit, Department of Medicine, Bangkok Metropolitan Medical College and Vajira Hospital, 681 Samsen Road, Dusit, Bangkok 10300, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Density* / drug effects
Calcium / therapeutic use
Cross-Sectional Studies
Dietary Supplements
Female
Glucocorticoids / adverse effects,  therapeutic use
Humans
Lumbar Vertebrae / metabolism
Lupus Erythematosus, Systemic / drug therapy,  metabolism*
Middle Aged
Prednisolone / adverse effects,  therapeutic use
Premenopause / metabolism*
Regression Analysis
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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