Document Detail


Bone mineral density in perimenopausal women with asthma: a population-based cross-sectional study.
MedLine Citation:
PMID:  10194163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is not known whether asthma constitutes a risk factor for osteoporosis or what the impact is of inhaled corticosteroids on bone mineral density (BMD). The study population (n = 3,222) was a random stratified sample from the Kuopio Osteoporosis Study, which included all women 47 to 56 yr of age residing in Kuopio Province, Eastern Finland. Spinal and femoral BMDs were measured using dual-energy X-ray absorptiometry. The BMD values of 119 asthmatics were cross-sectionally compared with those of 3,103 nonasthmatics. Of the 119 asthmatic women, 28 had not used corticosteroids, 65 had used oral corticosteroids, and 26 had used only inhaled corticosteroids. The asthmatics with no hormone replacement therapy (HRT) (n = 83) had lower mean spinal and femoral BMD value than did the corresponding nonasthmatics (spinal BMD, 1.083 +/- 0.150 [SD] versus 1.128 +/- 0.160 g/cm2, p < 0.05; femoral BMD, 0.894 +/- 0.112 [SD] versus 0.929 +/- 0.128 g/cm2, p < 0.05). Although BMDs were not significantly decreased in the asthmatics who had used inhaled corticosteroids, the duration of use correlated negatively with spinal BMD and was also associated with spinal BMD in multiple regression analysis. In perimenopausal women, asthma is associated with decreased bone density. This may be due to the corticosteroids rather than to the disease itself. However, HRT appears to be protective against bone loss also in asthmatics.
Authors:
A K Laatikainen; H P Kröger; H O Tukiainen; R J Honkanen; S V Saarikoski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  159     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1179-85     Citation Subset:  AIM; IM    
Affiliation:
Departments of Respiratory Medicine, Surgery, and Obstetrics and Gynecology, Kuopio University Hospital, Research Institute of Public Health, University of Kuopio, Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Anti-Asthmatic Agents / therapeutic use
Asthma / complications,  drug therapy,  pathology*
Bone Density*
Cross-Sectional Studies
Estrogen Replacement Therapy
Female
Femur Neck / radiography
Glucocorticoids / adverse effects,  therapeutic use
Humans
Middle Aged
Osteoporosis / chemically induced,  etiology,  radiography
Osteoporosis, Postmenopausal / complications,  prevention & control,  radiography
Risk Factors
Spine / radiography
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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