| Bone mineral density in patients with recently diagnosed, active rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 17456523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Osteoporosis is a well-known extra-articular phenomenon in patients with uncontrolled, long-standing rheumatoid arthritis (RA). In the present study, the extent of osteoporosis and reduced bone mineral density (BMD) and the disease-related and demographic factors that are associated with osteoporosis and reduced BMD were examined in patients with recently diagnosed, active RA. METHODS: BMD of the total hip and the lumbar spine was measured using dual-energy x ray absorptiometry in 381 patients with recently diagnosed active RA, who had never been treated with DMARDs or corticosteroids. Osteoporosis was defined as a T score <or=-2.5 SD and reduced BMD as Z score <or=-1 SD. Multivariate logistic regression analyses were performed to detect associations of osteoporosis and reduced BMD with disease activity, functional disability, joint damage (Sharp-van der Heijde score) and demographic factors. RESULTS: Osteoporosis and reduced BMD were found in the spine and/or the hip in 11% and 25%, respectively, of the patients. Longer symptom duration and presence of rheumatoid factor (RF) were the only RA-specific markers for osteoporosis and reduced BMD. Further, postmenopausal status in women, a low body mass index, familial osteoporosis, and, remarkably, male gender, were independently associated with osteoporosis and reduced BMD. CONCLUSION: In patients with recently diagnosed active RA who had never been treated with DMARDs or corticosteroids, BMD seems to be well-preserved and predominantly related to demographic factors. Longer symptom duration and a positive RF, but not higher disease activity or more joint damage, were related to osteoporosis and reduced BMD. |
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Authors:
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M Güler-Yüksel; J Bijsterbosch; Y P M Goekoop-Ruiterman; J K de Vries-Bouwstra; H K Ronday; A J Peeters; J M de Jonge-Bok; F C Breedveld; B A C Dijkmans; C F Allaart; W F Lems |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-04-24 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 66 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-15 Completed Date: 2007-11-09 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 1508-12 Citation Subset: IM |
Affiliation:
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Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands. m.yuksel@lumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adult Aged Arthritis, Rheumatoid / complications, physiopathology* Biological Markers / blood Body Mass Index Bone Density* Female Hip Joint / physiopathology Humans Lumbar Vertebrae / physiopathology Male Middle Aged Osteoporosis / etiology Osteoporosis, Postmenopausal / etiology Rheumatoid Factor / blood Risk Factors Severity of Illness Index Sex Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9009-79-4/Rheumatoid Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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