Document Detail

Bone mineral density in patients with recently diagnosed, active rheumatoid arthritis.
MedLine Citation:
PMID:  17456523     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Osteoporosis is a well-known extra-articular phenomenon in patients with uncontrolled, long-standing rheumatoid arthritis (RA). In the present study, the extent of osteoporosis and reduced bone mineral density (BMD) and the disease-related and demographic factors that are associated with osteoporosis and reduced BMD were examined in patients with recently diagnosed, active RA.
METHODS: BMD of the total hip and the lumbar spine was measured using dual-energy x ray absorptiometry in 381 patients with recently diagnosed active RA, who had never been treated with DMARDs or corticosteroids. Osteoporosis was defined as a T score <or=-2.5 SD and reduced BMD as Z score <or=-1 SD. Multivariate logistic regression analyses were performed to detect associations of osteoporosis and reduced BMD with disease activity, functional disability, joint damage (Sharp-van der Heijde score) and demographic factors.
RESULTS: Osteoporosis and reduced BMD were found in the spine and/or the hip in 11% and 25%, respectively, of the patients. Longer symptom duration and presence of rheumatoid factor (RF) were the only RA-specific markers for osteoporosis and reduced BMD. Further, postmenopausal status in women, a low body mass index, familial osteoporosis, and, remarkably, male gender, were independently associated with osteoporosis and reduced BMD.
CONCLUSION: In patients with recently diagnosed active RA who had never been treated with DMARDs or corticosteroids, BMD seems to be well-preserved and predominantly related to demographic factors. Longer symptom duration and a positive RF, but not higher disease activity or more joint damage, were related to osteoporosis and reduced BMD.
M Güler-Yüksel; J Bijsterbosch; Y P M Goekoop-Ruiterman; J K de Vries-Bouwstra; H K Ronday; A J Peeters; J M de Jonge-Bok; F C Breedveld; B A C Dijkmans; C F Allaart; W F Lems
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-04-24
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  66     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-11-09     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1508-12     Citation Subset:  IM    
Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
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MeSH Terms
Absorptiometry, Photon
Arthritis, Rheumatoid / complications,  physiopathology*
Biological Markers / blood
Body Mass Index
Bone Density*
Hip Joint / physiopathology
Lumbar Vertebrae / physiopathology
Middle Aged
Osteoporosis / etiology
Osteoporosis, Postmenopausal / etiology
Rheumatoid Factor / blood
Risk Factors
Severity of Illness Index
Sex Factors
Time Factors
Reg. No./Substance:
0/Biological Markers; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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