| Bone mineral density in cystic fibrosis: benefit of exercise capacity. | |
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MedLine Citation:
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PMID: 18619882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the association between bone mineral density (BMD) and objective maximal exercise measurements in adults with cystic fibrosis (CF). Twenty-five CF patients (19 males, 6 females, mean age 25.5 yr, range: 17-52) underwent BMD assessment and maximal-cycle ergometer exercise testing. We examined the relationship between gas exchange (% peak-predicted O(2) uptake, CO(2) output, O(2) saturation), exercise performance (maximum power, exercise duration), and respiratory mechanics (tidal volume, rate) with lumbar spine and total proximal femur BMD. The strongest clinical correlate with BMD was forced expiratory volume at 1s (lumbar spine Z-score, r=0.36; total proximal femur Z-score, r=0.68, p<0.01). The strongest exercise correlate was % peak-predicted O(2) uptake (lumbar spine Z-score, r=0.44, p<0.01; total proximal femur Z-score, r=0.59, p<0.01). There was a closer association between exercise parameters and total proximal femur BMD (r=0.43-0.60) than with lumbar spine BMD (r=0.04-0.45). Multiple regression analysis revealed VO(2) to be the strongest independent predictor of BMD (R(2)=0.86, p<0.001) followed by petCO(2) and body mass index (R(2)=0.7 and 0.5, respectively, p<0.01). Exercise appears to influence total proximal femur BMD more than lumbar spine BMD in CF. Exercise rehabilitation programs focusing on peripheral strength training may benefit those CF patients with low total proximal femur BMD. |
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Authors:
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Jonathan D Dodd; Sinead C Barry; Rupert B M Barry; Tom J Cawood; Malachi J McKenna; Charles G Gallagher |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-10 |
Journal Detail:
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Title: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry Volume: 11 ISSN: 1094-6950 ISO Abbreviation: J Clin Densitom Publication Date: 2008 Oct-Dec |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808212 Medline TA: J Clin Densitom Country: United States |
Other Details:
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Languages: eng Pagination: 537-42 Citation Subset: IM |
Affiliation:
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Department of Radiology, St. Vincent's University Hospital, Dublin, Ireland. j.dodd@st-vincents.ie |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adolescent Adult Bone Density / physiology* Cystic Fibrosis / genetics, physiopathology* Exercise / physiology* Exercise Test Female Femur / radiography Genotype Humans Lumbar Vertebrae / radiography Male Middle Aged Oxygen Consumption / physiology Predictive Value of Tests Regression Analysis Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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