| Bone mineral density in children with steroid-sensitive nephrotic syndrome. | |
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MedLine Citation:
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PMID: 19936659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To observe the influence of prednisolone treatment on bone mineral density (BMD) in children with idiopathic nephrotic syndrome. METHODS: Duel-energy X-ray absorptiometry of lumbar spine (L1-L4) was performed on 40 patients (18 first episode and 22 relapsers) of steroid sensitive idiopathic nephrotic syndrome. RESULTS: Patients of first episode and relapsers had comparable values of mean age, weight, height, body mass index, serum calcium, phosphate, spine area, bone mineral content (BMC) and BMD. Relapsing nephrotic syndrome patients received significantly higher mean total cumulative dose of prednisolone in comparison to first episode (p<0.001). The BMD Z-scores were normal in 39 of 40 (97.5%) patients. On regression analysis, it was found that both BMC and BMD did not correlate with cumulative dose of prednisolone, when other co-variants such as age, weight, height and spine area were adjusted. CONCLUSION: Bone mineral density in steroid sensitive nephrotic syndrome is unaffected by cumulative dose of prednisolone therapy both in first episode as well as relapser group of patients. |
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Authors:
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O P Mishra; S K Meena; S K Singh; R Prasad; R N Mishra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 76 ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 1237-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. opmpedia@yahoo.co.uk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Anti-Inflammatory Agents / administration & dosage, adverse effects* Bone Demineralization, Pathologic / chemically induced*, etiology Bone Density / drug effects* Case-Control Studies Child Child, Preschool Dose-Response Relationship, Drug Female Humans India Male Nephrotic Syndrome / complications, drug therapy* Prednisolone / administration & dosage, adverse effects* Recurrence Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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