Document Detail

Bone mineral density in children with neurofibromatosis 1.
MedLine Citation:
PMID:  17608828     Owner:  NLM     Status:  MEDLINE    
AIM: Our aim was to detect the status of bone mineral density (BMD) in children with NF1, and thus to help the management of the skeletal complications of NF1. METHODS: Dual-energy X-ray absorptiometry (DEXA) was performed in lumbar spine, total body, proximal femur and forearm in 31 children (3.1-18 years) with NF1. Correlations among the BMD values of four regions were calculated statistically. Z-scores of lumbar- and total body-BMD were also evaluated in 24 patients at and older than 5 years. RESULTS: Eleven children had skeletal findings, including mild scoliosis in 5 patients. No case with total body-Z score <-2 was detected. Lumbar-Z score was lower than -2 in 3 out of 24 cases. Patients with any skeletal involvement of NF1 were likely to have a lumbar-BMD lower than -2 in comparison with patients with no skeletal finding (odds ratio 4; 95% CI 0.01-4.62). Proximal femur-BMD values (g/cm(2)), yet forearm-BMDs, were correlated with both lumbar- and total body-BMD, regardless of skeletal involvements of NF1. CONCLUSIONS: Our findings suggest that lumbar- or proximal femur-DEXA, rather than forearm- or total body-DEXA, could reveal significantly decreased BMD in children with NF1, especially in those with skeletal involvement of NF1.
Kutluhan Yilmaz; Meral Ozmen; Suleyman Bora Goksan; Nurten Eskiyurt
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Publication Detail:
Type:  Journal Article     Date:  2007-07-03
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-10-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1220-2     Citation Subset:  IM    
Pediatrician and Pediatric Neurologist, Department of Pediatrics, Gaziantep University, Faculty of Medicine, Turkey.
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MeSH Terms
Absorptiometry, Photon
Body Composition / physiology
Bone Density / physiology*
Bone Diseases, Metabolic / physiopathology
Child, Preschool
Exercise / physiology
Leg Bones / physiopathology,  radiography
Neurofibromatosis 1 / complications,  physiopathology*
Spine / physiopathology,  radiography

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