Document Detail

Bone mineral density in adult patients treated with various antiepileptic drugs.
MedLine Citation:
PMID:  22541979     Owner:  NLM     Status:  MEDLINE    
There is considerable evidence suggesting, that older antiepileptic drugs (AEDs) and some of the newer ones decrease bone mineral density (BMD). However, there is only limited and conflicting data concerning the effect of levetiracetam on BMD. In this cross-sectional study we analysed data from 168 adult consecutive outpatients treated with AEDs for more than 2 years, and who underwent measurement of the BMD. We compared the incidence of decreased BMD among the patients treated with 6 different AEDs: carbamazepine (CBZ), oxcarbazepine (OXC), valproic acid (VPA), lamotrigine (LTG), topiramate (TPM) and levetiracetam (LEV). Among the patients on monotherapy, reduced BMD was present significantly most often in patients treated with LEV and those treated with OXC. In the group of patients on polytherapy there was no significant difference in the incidence of low BMD among patients treated with various AEDs. Our data suggest that patients on long-term treatment with LEV have a higher risk for affection of bone density.
Simona Alexandra Beniczky; Janina Viken; Lars Thorbjørn Jensen; Noémi Becser Andersen
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Publication Detail:
Type:  Journal Article     Date:  2012-04-26
Journal Detail:
Title:  Seizure     Volume:  21     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-10-15     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  471-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Absorptiometry, Photon
Anticonvulsants / administration & dosage,  adverse effects*
Bone Density / drug effects*
Carbamazepine / administration & dosage,  adverse effects,  analogs & derivatives
Cross-Sectional Studies
Drug Therapy, Combination
Fructose / administration & dosage,  adverse effects,  analogs & derivatives
Middle Aged
Piracetam / administration & dosage,  adverse effects,  analogs & derivatives
Triazines / administration & dosage,  adverse effects
Valproic Acid / administration & dosage,  adverse effects
Young Adult
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 0H73WJJ391/topiramate; 230447L0GL/etiracetam; 30237-26-4/Fructose; 33CM23913M/Carbamazepine; 614OI1Z5WI/Valproic Acid; U3H27498KS/lamotrigine; VZI5B1W380/oxcarbazepine; ZH516LNZ10/Piracetam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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