| Bone mineral density and hip structural analysis in type 1 diabetic men. | |
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MedLine Citation:
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PMID: 17218735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The risk of non-vertebral fractures is increased in men with type 1 diabetes (DM1) but studies have shown only moderately decreased or normal bone mineral density (BMD) in these patients. No previous studies have evaluated hip strength and geometry indices in DM1 patients. This study was therefore designed to characterize associations between BMD, dual X-ray absorptiometry (DXA)-based hip strength indices, metabolic control, and DM1chronic complications. DESIGN AND METHODS: The study was performed on 36 males aged 43.6 +/- 5.1 years with long-lasting DM1 and 36 healthy males matched for age, weight, and height. BMD in lumbar spine, total hip, upper and lower part of the femoral neck, hip axis length, cross-sectional area and moment of inertia (CSMI), and glycated hemoglobin (HbA1c) were measured. RESULTS: DM1 men had decreased spine BMD (P < 0.05) and normal total hip BMD in comparison with controls. Hip geometry and strength indices were comparable in both groups. However, M1 men had decreased CSMI and upper femur BMD but these differences did not reach statistical significance (P = 0.06). BMD changes and hip strength parameters did not correlate with HbA1c. CONCLUSIONS: Middle-aged DM1 men have decreased lumbar spine BMD, normal hip BMD and normal hip strength indices. These changes are not influenced by metabolic control and presence of chronic microvascular complications. |
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Authors:
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Tomasz Miazgowski; Slawomir Pynka; Marzena Noworyta-Zietara; Barbara Krzyzanowska-Swiniarska; Robert Pikul |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 156 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-12 Completed Date: 2007-03-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 123-7 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Hypertension and Metabolic Diseases Pomeranian Medical University, Szczecin, Poland. miazgowski@interia.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adult Anthropometry Biomechanics Bone Density / physiology* Diabetes Complications / metabolism, pathology Diabetes Mellitus, Type 1 / metabolism*, pathology* Femur Neck / pathology Hemoglobin A, Glycosylated / metabolism Hip / pathology* Humans Male |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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