Document Detail

Bone mineral density and bone turnover in patients with psoriatic arthritis.
MedLine Citation:
PMID:  17876648     Owner:  NLM     Status:  MEDLINE    
Psoriasis is a common inflammatory skin disease, and conflicting data have been published about osteoporosis and bone turnover markers in patients with psoriatic arthritis. The aim of this study was to assess bone mineral density (BMD) and bone turnover markers in psoriatic patients with and without peripheral arthritis and to investigate the relationship between clinical parameters and markers of bone turnover. Forty-seven patients (24 women, 23 men) with psoriasis were included to the study. Demographic data and clinical characteristics were recorded. Erythrocyte sedimentation rate and C-reactive protein were assessed as disease activity parameters. BMD was determined for lumbar spine and total hip by dual X-ray absorptiometry (DXA). Serum Ca, P, alkalen phosphatase (ALP), and serum type I collagen cross-linked C telopeptide (CTX) were measured as bone turnover markers in all patients. The patients were divided into two groups according to their peripheral arthritis status. The clinical and laboratory variables, as well as bone mass status of the groups, were compared with each other. Eighteen patients had peripheral arthritis. All the female patients were premenopausal. None of the patients had radiologically assessed axial involvement. There was no significant difference between the BMD levels of psoriatic patients with and without arthropathy. One patient (5%) had osteoporosis, and nine (50%) patients had osteopenia in arthritic group, while eight (27.5%) patients had osteopenia in patients without arthritis. Serum CTX, ALP, Ca, and P levels were not significantly different in arthritic than in non-arthritic patients (p > 0.05). In patients with psoriatic arthritis, the duration of arthritis was negatively correlated with BMD values of lumbar spine and total femur and serum CTX levels, suggesting an association of increased demineralization with the duration of joint disease. In conclusion, psoriatic patients with peripheral arthritis with longer duration of joint disease may be at a risk for osteoporosis, which can require preventative treatment efforts.
Pinar Borman; Seçil Babaoğlu; Guneş Gur; Sezin Bingol; Hatice Bodur
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Publication Detail:
Type:  Journal Article     Date:  2007-09-18
Journal Detail:
Title:  Clinical rheumatology     Volume:  27     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
Clinic of Physical Medicine and Rehabilitation II, Numune Training and Research Hospital, Samanpazari, Ankara, Turkey.
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MeSH Terms
Absorptiometry, Photon
Alkaline Phosphatase / blood
Arthritis, Psoriatic / complications,  metabolism*,  physiopathology*
Biological Markers / blood
Bone Density / physiology*
Bone Diseases, Metabolic / blood,  etiology
Bone and Bones / metabolism*
C-Reactive Protein / metabolism
Calcium / blood
Case-Control Studies
Collagen Type I / blood
Middle Aged
Osteoporosis / blood,  etiology
Peptides / blood
Phosphorus / blood
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 7440-70-2/Calcium; 7723-14-0/Phosphorus; 9007-41-4/C-Reactive Protein; EC Phosphatase

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