| Bone mineral densitometry in patients on hemodialysis: difference between genders and what to measure. | |
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MedLine Citation:
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PMID: 20370444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Chronic kidney disease (CKD) and osteoporosis are important health problems. There is an interrelationship between osteoporosis and CKD. Bone densitometry is the "gold" standard in the diagnosis of osteoporosis. Unfortunately, there are some problems with the interpretation of bone densitometry in CKD patients. The goal of this study was to determine bone mineral density (BMD) in CKD patients, to assess the difference between genders and different sites of bone densitometry correlation between BMD and laboratory parameters, and to assess the most optimal measuring site. METHODS: We studied 134 hemodialysis (HD) patients (62 females, 72 males). The mean age was 56.4+/-12.4 years and the mean duration of HD was 54.4+/-60 months. BMD of the lumbar spine (posterior-anterior projection and lateral projection), hip (femoral neck, trochanter, intertrochanter, total femur, the Ward's Triangle), and forearm (ultradistal (UD), middistal (MID), distal third portion, and total forearm) was measured using dual X-ray absorptiometry (DXA) (Hologic Delphi apparatus). Values were expressed as BMD, T-score, and Z-score. RESULTS: Females had lower values of BMD in all measurement points. There were no significant differences in T- and Z-scores of forearm between males and females. Age was in a positive correlation with lumbar spine BMD in males and females. There was a negative correlation with neck and forearm BMD in both groups. Serum parathyroid hormone (PTH) was also in negative correlation with hip and forearm BMD in both groups. The best correlation of BMD in different sites was between forearm and neck. CONCLUSION: BMD data in CKD patients should be interpreted with caution and appendicular skeletal sites should be included in the evaluation. |
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Authors:
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Lidija Orlic; Zeljka Crncevic; Drasko Pavlovic; Luka Zaputovic |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Renal failure Volume: 32 ISSN: 1525-6049 ISO Abbreviation: Ren Fail Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: England |
Other Details:
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Languages: eng Pagination: 300-8 Citation Subset: IM |
Affiliation:
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Department of Nephrology, University Hospital Rijeka, Rijeka, Croatia. lidija.orlic@ri.t-com.hr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Alkaline Phosphatase / blood Bone Density* Bone Diseases, Metabolic / diagnosis*, etiology Calcium / blood Chronic Disease Female Forearm / radiography Hip / radiography Humans Kidney Diseases / complications, therapy Lumbar Vertebrae / radiography Male Middle Aged Osteoporosis / diagnosis, etiology Parathyroid Hormone / blood Phosphorus / blood Renal Dialysis* Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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