Document Detail


Bone mineral changes during pregnancy and lactation.
MedLine Citation:
PMID:  12014704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant calcium transfer from the mother to the fetus and infant occurs during pregnancy and lactation, theoretically placing the mother at an increased risk for osteoporosis later in life. During pregnancy, intestinal calcium absorption increases to meet much of the fetal calcium needs. Maternal bone loss also may occur in the last months of pregnancy, a time when the fetal skeleton is rapidly mineralizing. The calcium needed for breast milk production is met through renal calcium conservation and, to a greater extent, by mobilization of calcium from the maternal skeleton. Women experience a transient loss of approx 3-7% of their bone density during lactation, which is rapidly regained after weaning. The rate and extent of recovery are influenced by the duration of lactation and postpartum amenorrhea and differ by skeletal site. Additional calcium intake does not prevent bone loss during lactation or enhance the recovery after weaning. The recovery of bone is complete for most women and occurs even with shortly spaced pregnancies. Epidemiologic studies have found that pregnancy and lactation are not associated with an increased risk of osteoporotic fractures.
Authors:
Heidi J Kalkwarf; Bonny L Specker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrine     Volume:  17     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-11-19     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Affiliation:
Division of General & Community Pediatrics, Children's Hospital Medical Center, Cincinnati, OH 45229, USA. heidi.kalkwarf@chmcc.org
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Bone Density
Bone and Bones / injuries,  metabolism*
Calcium / metabolism
Female
Fractures, Bone
Homeostasis
Humans
Lactation / physiology*
Minerals / metabolism*
Pregnancy / physiology*
Risk Factors
Chemical
Reg. No./Substance:
0/Minerals; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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