Document Detail


Bone metabolism in pregnant women exposed to single compared with multiple courses of corticosteroids.
MedLine Citation:
PMID:  18515519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare markers of maternal bone metabolism between women who received a single compared with multiple courses of antenatal corticosteroids.
METHODS: This is an analysis of serum samples from a previously reported randomized, placebo-controlled, multicenter trial. Women at risk for preterm delivery after an initial course of corticosteroids were randomly assigned to weekly courses of betamethasone (active) or placebo. Serum levels of carboxy terminal propeptide of type I procollagen (PICP) and cross-linked carboxy terminal telopeptide of type I collagen (ICTP) were measured to assess the rate of bone formation and resorption, respectively, at three time points. The placebo group (n=93) was compared with the active group, receiving four or more courses of betamethasone (n=112).
RESULTS: There were significant (P<.001) increases in PICP and ICTP between baseline and delivery in both groups. Cross-linked carboxy terminal telopeptide of type I collagen, but not PICP, was lower with corticosteroid exposure immediately before administration of the fourth study course (P<.001). No significant differences in PICP and ICTP were seen between groups at delivery.
CONCLUSION: Increasing levels of PICP and ICTP with advancing gestation are consistent with physiologic changes in maternal bone metabolism. Multiple courses of corticosteroids for fetal maturation are not associated with persistent or cumulative effects on maternal bone metabolism as measured by PICP and ICTP.
LEVEL OF EVIDENCE: II.
Authors:
Mary A Carroll; Alex C Vidaeff; Lisa Mele; Ronald J Wapner; Brian Mercer; Alan M Peaceman; Yoram Sorokin; Donald J Dudley; Catherine Y Spong; Kenneth J Leveno; Margaret Harper; Steve N Caritis; Menachem Miodovnik; John M Thorp; Atef Moawad; Mary J O'Sullivan; Marshall W Carpenter; Dwight J Rouse; Baha Sibai;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  111     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-07-24     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1352-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Betamethasone / administration & dosage*,  adverse effects*
Biological Markers / blood*
Bone and Bones / drug effects,  metabolism*
Collagen Type I / blood*
Double-Blind Method
Female
Glucocorticoids / administration & dosage*,  adverse effects*
Humans
Obstetric Labor, Premature / prevention & control
Peptide Fragments / blood*
Peptides / blood*
Pregnancy
Procollagen / blood*
Grant Support
ID/Acronym/Agency:
HD21410/HD/NICHD NIH HHS; HD21414/HD/NICHD NIH HHS; HD27860/HD/NICHD NIH HHS; HD27861/HD/NICHD NIH HHS; HD27869/HD/NICHD NIH HHS; HD27905/HD/NICHD NIH HHS; HD27915/HD/NICHD NIH HHS; HD27917/HD/NICHD NIH HHS; HD34116/HD/NICHD NIH HHS; HD34136/HD/NICHD NIH HHS; HD34208/HD/NICHD NIH HHS; HD36801/HD/NICHD NIH HHS; HD40485/HD/NICHD NIH HHS; HD40500/HD/NICHD NIH HHS; HD40512/HD/NICHD NIH HHS; HD40544/HD/NICHD NIH HHS; HD40545/HD/NICHD NIH HHS; HD40560/HD/NICHD NIH HHS; M01 RR000080/RR/NCRR NIH HHS; M01 RR000080-45/RR/NCRR NIH HHS; M01-RR-000080/RR/NCRR NIH HHS; U10 HD021410/HD/NICHD NIH HHS; U10 HD021410-22/HD/NICHD NIH HHS; U10 HD021414-15/HD/NICHD NIH HHS; U10 HD027860-15/HD/NICHD NIH HHS; U10 HD027861-10/HD/NICHD NIH HHS; U10 HD027869-10/HD/NICHD NIH HHS; U10 HD027905-10/HD/NICHD NIH HHS; U10 HD027915-18/HD/NICHD NIH HHS; U10 HD027917/HD/NICHD NIH HHS; U10 HD027917-18/HD/NICHD NIH HHS; U10 HD034116-13/HD/NICHD NIH HHS; U10 HD034122-05/HD/NICHD NIH HHS; U10 HD034136/HD/NICHD NIH HHS; U10 HD034136-07/HD/NICHD NIH HHS; U10 HD034208/HD/NICHD NIH HHS; U10 HD034208-12/HD/NICHD NIH HHS; U10 HD036801/HD/NICHD NIH HHS; U10 HD036801-11/HD/NICHD NIH HHS; U10 HD040485/HD/NICHD NIH HHS; U10 HD040485-09/HD/NICHD NIH HHS; U10 HD040500-08/HD/NICHD NIH HHS; U10 HD040512-09/HD/NICHD NIH HHS; U10 HD040544-09/HD/NICHD NIH HHS; U10 HD040545/HD/NICHD NIH HHS; U10 HD040545-09/HD/NICHD NIH HHS; U10 HD040560-09/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Glucocorticoids; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/collagen type I trimeric cross-linked peptide; 0/procollagen type I carboxy terminal peptide; 9842X06Q6M/Betamethasone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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