Document Detail


Bone maturation in extremely low birth weight infants in relation to birth weight and endocrine parameters.
MedLine Citation:
PMID:  19277708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Modern intensive care techniques have led to higher survival rates of extremely low birth weight infants (ELBW, birth weight <1,000 g). Previous studies have suggested a link between abnormal birth parameters and subsequent endocrine disturbances, but a possible impact on bone maturation during childhood has not been studied. ELBW children were studied (mean chronological age (CA), 6.01 years; range, 4.5-8.2). Skeletal maturation was assessed according to Greulich and Pyle (8). Bone age (BA) was defined as retarded when DeltaBA-CA was < -1 SD and accelerated when DeltaBA-CA was >+1 SD. BA was either retarded or accelerated in 15 patients (24.6%). Twenty-one of 61 radiograms (34.4%) showed a discordant BA with a marked gender difference (14/24 boys; 7/37 girls). DeltaBA-CA correlated significantly with BMI (r = 0.36; p = 0.005) and height SDS (r = 0.35; p = 0.006). We found significant correlations between BA and androgens. Insulin-like growth factor binding protein-1 (IGFBP-1), which decreases in insulin-resistant individuals, correlated negatively with BA. In conclusion, bone maturation in ELBW children is correlative with height and weight. It is modulated by a variety of metabolic factors, including IGFBP-1 and androgens. Bone age, together with height and weight catch-up, can thus possibly serve as early indicators of insulin resistance later in life.
Authors:
Sonja Stutte; Joachim Woelfle; Marc Born; Peter Bartmann; Bettina C Gohlke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-11
Journal Detail:
Title:  European journal of pediatrics     Volume:  168     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-03     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1497-503     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Age Determination by Skeleton
Birth Weight
Body Mass Index
Bone Development / physiology*
Child
Dehydroepiandrosterone Sulfate / blood
Female
Follow-Up Studies
Humans
Infant, Extremely Low Birth Weight / blood,  physiology*
Infant, Newborn
Insulin Resistance / physiology
Insulin-Like Growth Factor Binding Protein 1 / blood*
Male
Sex Factors
Chemical
Reg. No./Substance:
0/IGFBP1 protein, human; 0/Insulin-Like Growth Factor Binding Protein 1; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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