| Bone mass and bone modelling markers in hypertensive postmenopausal women. | |
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MedLine Citation:
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PMID: 12574788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous phosphocalcium alterations associated with bone mineral density in hypertension have been described, but very few studies assess them. This study assesses bone mass in hypertensive postmenopausal women and the hypertension influence determining both calcium homeostasis and bone turnover markers. Blood and urine samples were analysed for calcium metabolism-related parameters. Densitometry studies were conducted in the lumbar spine (L2-L4). Hypertensive osteoporotic women--selected from 82 women, with 22% osteoporosis prevalence, similar to the rate for the same age in the Spanish population--had significantly higher levels of body mass index (29+/-4 vs 26+/-4, P=0.019), calciuria (293+/-146 vs 210+/-116 mg/24 h, P=0.023) and calcium/creatinine ratio (0.33+/-0.2 vs 0.22+/-0.1 P=0.003) vs hypertensive nonosteoporotic women. No relation was found between systolic and diastolic blood pressure with bone mass. However, there was a negative osteocalcin correlation (r=-0.386, P=0.0001, and r=-0.242, P=0.033). Calciuria is associated with bone mass decrease in hypertensive women, and there is no relation between bone mass and blood pressure. |
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Authors:
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J L Pérez-Castrillón; I Justo; J Silva; A Sanz; R Igea; P Escudero; C Pueyo; C Diaz; G Hernández; A Dueñas |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of human hypertension Volume: 17 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-07 Completed Date: 2003-05-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 107-10 Citation Subset: IM |
Affiliation:
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Departamento Medicina Interna, Facultad de Medicina, Hospital Univcersitario Rió Hortega, Cardenal Torquemada s/n, 47010 Valladolid, Spain. castrv@terra.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Body Mass Index Bone Density / physiology* Bone Remodeling / physiology* Calcium / blood, urine Calcium Metabolism Disorders / etiology*, metabolism* Female Humans Hypertension / complications*, metabolism* Middle Aged Osteoporosis, Postmenopausal / etiology*, metabolism* Postmenopause / metabolism* Severity of Illness Index Sex Factors |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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