Document Detail

Bone mass and bone modelling markers in hypertensive postmenopausal women.
MedLine Citation:
PMID:  12574788     Owner:  NLM     Status:  MEDLINE    
Numerous phosphocalcium alterations associated with bone mineral density in hypertension have been described, but very few studies assess them. This study assesses bone mass in hypertensive postmenopausal women and the hypertension influence determining both calcium homeostasis and bone turnover markers. Blood and urine samples were analysed for calcium metabolism-related parameters. Densitometry studies were conducted in the lumbar spine (L2-L4). Hypertensive osteoporotic women--selected from 82 women, with 22% osteoporosis prevalence, similar to the rate for the same age in the Spanish population--had significantly higher levels of body mass index (29+/-4 vs 26+/-4, P=0.019), calciuria (293+/-146 vs 210+/-116 mg/24 h, P=0.023) and calcium/creatinine ratio (0.33+/-0.2 vs 0.22+/-0.1 P=0.003) vs hypertensive nonosteoporotic women. No relation was found between systolic and diastolic blood pressure with bone mass. However, there was a negative osteocalcin correlation (r=-0.386, P=0.0001, and r=-0.242, P=0.033). Calciuria is associated with bone mass decrease in hypertensive women, and there is no relation between bone mass and blood pressure.
J L Pérez-Castrillón; I Justo; J Silva; A Sanz; R Igea; P Escudero; C Pueyo; C Diaz; G Hernández; A Dueñas
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  17     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
Departamento Medicina Interna, Facultad de Medicina, Hospital Univcersitario Rió Hortega, Cardenal Torquemada s/n, 47010 Valladolid, Spain.
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MeSH Terms
Age Factors
Body Mass Index
Bone Density / physiology*
Bone Remodeling / physiology*
Calcium / blood,  urine
Calcium Metabolism Disorders / etiology*,  metabolism*
Hypertension / complications*,  metabolism*
Middle Aged
Osteoporosis, Postmenopausal / etiology*,  metabolism*
Postmenopause / metabolism*
Severity of Illness Index
Sex Factors
Reg. No./Substance:

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