| Bone marrow stem cell transplantation and coronary artery bypass grafting surgery for chronic ischemic myocardiopathy. | |
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MedLine Citation:
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PMID: 20534416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied 12 consecutive patients with chronic ischemic myocardiopathy treated with bone marrow adult stem cell (ASC) transplantation and coronary artery bypass grafting (CABG). The aim of the study was to evaluate functional class (New York Heart Association), wall motion score index (WMSI), and ejection fraction by echocardiography and to evaluate myocardial perfusion by single-photon emission computed tomography (SPECT). Follow-up evaluations were performed at 3, 6, and 12 months. The results revealed functional class improvement until 12 months, a progressive increase in the ejection fraction of 15% to 20% in the first 6 months, and a progressive increase in the WMSI by 35% to 45% in 12 months. Evaluation of the WMSI in the stem cell and CABG areas separately revealed a similar improvement in the first 3 months and a better progression in the CABG area. SPECT images revealed perfusion improvements in ischemic areas and no difference in fibrous tissue areas. These preliminary results show the safety of the method and its reproducibility. When performed concomitantly with CABG, bone marrow ASC transplantation may improve functional class, ejection fraction, WMSI, and myocardial perfusion. This study will be completed with all patients followed up for 12 months and compared with a control group. |
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Authors:
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Danton Richlin da Rocha Loures; Juliano Mendes de Souza; Oaidia Adelina Nocetti Sermann; Noemi Farah; Maria Felicitas Niedfeld Rodriguez; Mariester Malvezzi; Tamara Borgonovo; Ricardo João Westphal; Lauro Ervilha; Claudio Pereira da Cunha |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The heart surgery forum Volume: 13 ISSN: 1522-6662 ISO Abbreviation: Heart Surg Forum Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2011-06-02 Revised Date: 2011-08-05 |
Medline Journal Info:
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Nlm Unique ID: 100891112 Medline TA: Heart Surg Forum Country: United States |
Other Details:
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Languages: eng Pagination: E161-4 Citation Subset: IM |
Affiliation:
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Paraná Federal University Clinics Hospital, Curitiba, Brazil. dantonloures@onda.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antigens, CD34 Biopsy, Fine-Needle Bone Marrow Transplantation / adverse effects*, statistics & numerical data Case-Control Studies Coronary Artery Bypass* Disease Progression Humans Male Myocardial Ischemia / diagnosis, surgery*, ultrasonography Myocardial Reperfusion Prospective Studies Stroke Volume Tomography, Emission-Computed, Single-Photon Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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