Document Detail


Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations.
MedLine Citation:
PMID:  18028479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Philadelphia-negative chronic myeloproliferative disorders (CMD) include polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Angiogenesis is critical in the pathogenesis of PMF. We studied angiogenesis in 115 patients with CMD (23 PV, 24 ET, 46 PMF, 12 post-PV and 10 post-ET myelofibrosis) by assessment of microvessel density (MVD) in bone marrow (BM). Kruskall-Wallis analysis of variance showed that patients with PMF had significantly higher values of MVD than those with PV (P < 0.001), ET (P < 0.001) and controls (P < 0.001). Mann-Whitney U-test demonstrated that patients with PMF at the prefibrotic stage had significantly higher MVD values than those with ET (P = 0.02). Patients with post-PV myelofibrosis showed significantly higher MVD values than those with PV (P < 0.001), as did patients with post-ET myelofibrosis compared with ET (P < 0.001). In patients with CMD, the multivariate generalized linear regression model showed that the JAK2 (V617F) mutational burden (P = 0.01), serum lactate dehydrogenase level (P = 0.003), and anaemia (P < 0.001) independently correlated with MVD. In summary, this study indicates that assessment of BM angiogenesis, as measured by MVD, may be a useful additional tool in the histopathological definition of CMD.
Authors:
Emanuela Boveri; Francesco Passamonti; Elisa Rumi; Daniela Pietra; Chiara Elena; Luca Arcaini; Cristiana Pascutto; Alessandro Castello; Mario Cazzola; Umberto Magrini; Mario Lazzarino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-19
Journal Detail:
Title:  British journal of haematology     Volume:  140     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-04-23     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Affiliation:
Department of Surgical Pathology, University of Pavia Medical School, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anemia / etiology
Bone Marrow / blood supply*
Chronic Disease
Female
Humans
Janus Kinase 2 / genetics
L-Lactate Dehydrogenase / blood
Male
Middle Aged
Mutation
Myeloproliferative Disorders / complications,  genetics,  pathology*
Neovascularization, Pathologic / pathology*
Polycythemia Vera / genetics,  pathology
Primary Myelofibrosis / genetics,  pathology
Thrombocythemia, Essential / genetics,  pathology
Chemical
Reg. No./Substance:
EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human

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