| Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. | |
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MedLine Citation:
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PMID: 20728948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events. |
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Authors:
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Bassem Yamout; Roula Hourani; Haytham Salti; Wissam Barada; Taghrid El-Hajj; Aghiad Al-Kutoubi; Aline Herlopian; Elizabeth Kfoury Baz; Rami Mahfouz; Rima Khalil-Hamdan; Nabeela M A Kreidieh; Marwan El-Sabban; Ali Bazarbachi |
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Publication Detail:
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Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-21 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 227 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 185-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. yamoutba@idm.net.lb |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Marrow Transplantation / adverse effects, immunology*, pathology Cells, Cultured Feasibility Studies Female Follow-Up Studies Humans Injections, Spinal Male Mesenchymal Stem Cell Transplantation / adverse effects, methods* Middle Aged Multiple Sclerosis / pathology*, surgery* Pilot Projects Transplantation, Autologous Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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