Document Detail


Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study.
MedLine Citation:
PMID:  20728948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events.
Authors:
Bassem Yamout; Roula Hourani; Haytham Salti; Wissam Barada; Taghrid El-Hajj; Aghiad Al-Kutoubi; Aline Herlopian; Elizabeth Kfoury Baz; Rami Mahfouz; Rima Khalil-Hamdan; Nabeela M A Kreidieh; Marwan El-Sabban; Ali Bazarbachi
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Publication Detail:
Type:  Clinical Trial, Phase I; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-21
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  227     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. yamoutba@idm.net.lb
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Marrow Transplantation / adverse effects,  immunology*,  pathology
Cells, Cultured
Feasibility Studies
Female
Follow-Up Studies
Humans
Injections, Spinal
Male
Mesenchymal Stem Cell Transplantation / adverse effects,  methods*
Middle Aged
Multiple Sclerosis / pathology*,  surgery*
Pilot Projects
Transplantation, Autologous
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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