Document Detail

Bone marrow involvement in malignant lymphoma without peripheral lymphadenopathy.
MedLine Citation:
PMID:  578338     Owner:  NLM     Status:  MEDLINE    
Twelve cases of non-Hodgkin's lymphoma and a single case of Hodgkin's disease were first diagnosed on bone marrow biopsy. None of the patients had superficially enlarged lymph nodes, and in 3 patients the histological examination of the biopsy specimen showed normal reactive nodes. Eight patients were over the age of 60. The differential diagnosis from benign nodular lymphoid hyperplasia is discussed, with emphasis on the cytology and the paratrabecular position of the lymphoid infiltrate. Ten patients had focal involvement of the bone marrow and 1 of the 3 patients with diffuse involvement had Hodgkin's disease. Lymphoid nodules occur normally in the bone marrow and we conclude that non-Hodgkin's lymphoma and Hodgkins's disease can arise primarily in the bone marrow.
W G Staples; E P Gétaz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  52     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-31     Completed Date:  1977-10-31     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  60-3     Citation Subset:  IM    
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MeSH Terms
Bone Marrow / pathology*
Diagnosis, Differential
Hodgkin Disease / pathology
Hyperplasia / diagnosis
Lymph Nodes / pathology*
Lymphoid Tissue
Lymphoma / diagnosis,  pathology*
Lymphoma, Non-Hodgkin / pathology
Middle Aged

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