| Bone marrow and intrathymic precursors of T-cells produce a factor which enhances colony formation in the spleen. | |
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MedLine Citation:
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PMID: 2102776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone marrow Ig-Thy-1-SC-1- stem cells (precursors of T-lymphocytes, PTL, containing the SC-1 antigen) spontaneously secrete a humoral factor. When bone marrow Ig-Thy-1-SC-1- cells were treated with this factor they became able to form haemopoietic colonies in the spleens of lethally irradiated mice. This new colony-stimulating factor (CSF) is thermostable and has a molecular mass of about 25-30 kDa. Production of the CSF by bone marrow SC-1+Thy-1- cells was stimulated by treatment with the thymus preparation Thymoptin. Such treatment of bone marrow SC-1+Thy-1- cells also induced the production of a suppressor factor (thermolabile, molecular mass about 45 kDa), that reversed the effect of the CSF. The CSF and the suppressor factor are both also produced by cortisone-resistant radioresistant L3T4-Lyt-2-SC-1+ thymocytes (i.e. intrathymic PTL). The regulation of haemopoiesis appears to be a normal function of bone marrow PTL. |
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Authors:
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A A Yarilin; I V Miroshnichenko; N I Sharova; Talaev VYu; I D Ryabinina; V P Shichkin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedical science Volume: 1 ISSN: 0955-9701 ISO Abbreviation: Biomed. Sci. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1991-10-01 Completed Date: 1991-10-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9010320 Medline TA: Biomed Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
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Institute of Immunology, Ministry of Health of the USSR, Moscow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow / metabolism* Bone Marrow Cells Cell Fractionation Cell Line Colony-Stimulating Factors / metabolism*, physiology Hematopoietic Stem Cells / cytology, metabolism* Male Mice Mice, Inbred CBA Peptides / physiology Spleen / cytology, metabolism* T-Lymphocytes / cytology* Thymosin* / analogs & derivatives* Thymus Extracts / physiology |
| Chemical | |
Reg. No./Substance:
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0/Colony-Stimulating Factors; 0/Peptides; 0/Thymus Extracts; 120798-94-9/timoptin; 61512-21-8/Thymosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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