Document Detail


Bone marrow in leukemia and aplastic anemia: MR imaging before, during, and after treatment.
MedLine Citation:
PMID:  3544034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serial magnetic resonance (MR) studies of the cervical bone marrow were performed in five patients undergoing bone marrow transplantation for chronic granulocytic leukemia and in four patients with aplastic anemia who were treated with antilymphocytic globulin. Findings were compared with those from a group of healthy volunteers. Chemical shift imaging techniques were used to exploit the presence of protons in fat and water in the red marrow. Characteristic changes were seen in aplastic anemia before treatment, but derivation of images representing fat and water fractions was necessary to distinguish leukemic marrow. Acute changes during the treatment of leukemia may reflect the effects of chemotherapy and radiation therapy, whereas changes in the chronic phase of both diseases may prove useful in predicting treatment outcome. MR studies are likely to be useful in the assessment and treatment of hematologic disorders.
Authors:
C S McKinstry; R E Steiner; A T Young; L Jones; D Swirsky; V Aber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  162     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-03-23     Completed Date:  1987-03-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  701-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Aplastic / pathology*,  therapy
Antilymphocyte Serum / therapeutic use
Bone Marrow / pathology*
Bone Marrow Transplantation
Female
Humans
Leukemia, Myeloid / pathology*,  therapy
Magnetic Resonance Spectroscopy / diagnostic use*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antilymphocyte Serum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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