Document Detail


Bone marrow histomorphology and JAK2 mutation status in essential thrombocythemia.
MedLine Citation:
PMID:  18092959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A retrospective study of 38 essential thrombocythemia (ET) patients was conducted, reviewing bone marrow biopsies according to WHO criteria using a semiquantitative scoring system. Four patients did not fulfil the WHO criteria for a myeloproliferative disorder and one biopsy was insufficient for evaluation. 14 patients were reclassified as having prefibrotic idiopathic myelofibrosis (IMF), whilst the ET diagnosis was sustained in 19 patients. The individual bone marrow parameters of the reviewed diagnosis showed no correlation with JAK2 V617F mutation status, which was determined by a highly sensitive quantitative real-time PCR (qPCR) method. However, we could confirm previous findings of higher haemoglobin and lower platelet levels in the JAK2 V617F positive patients. Thus, the well-established phenotypic relationship of JAK2-positive ET and PV at the biochemical and molecular level was not recorded as regards bone marrow morphology according to the WHO criteria. Accordingly, the WHO concept of two distinct entities, ET and prefibrotic IMF, does not seem to fit the model of JAK2-positive ET as part of a biological continuum of JAK2 V617F-positive chronic myeloproliferative disorders.
Authors:
Thomas Stauffer Larsen; Hans Carl Hasselbalch; Niels Pallisgaard; Michael Boe Møller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  115     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-04-01     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1267-73     Citation Subset:  IM    
Affiliation:
Department of Haematology and Pathology, Odense University Hospital, Denmark. thomas.stauffer.larsen@ouh.regionsyddanmark.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Amino Acid Substitution
Biopsy
Bone Marrow / pathology*
Erythropoiesis
Fibrosis / pathology
Granulocytes / pathology
Hemoglobins / metabolism
Humans
Janus Kinase 2 / genetics*
Macrophages / pathology
Megakaryocytes / pathology
Middle Aged
Mutation
Platelet Count
Polymerase Chain Reaction
Retrospective Studies
Stromal Cells / pathology
Thrombocythemia, Essential / blood,  genetics*,  pathology*
Chemical
Reg. No./Substance:
0/Hemoglobins; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human

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