| Bone marrow histomorphology and JAK2 mutation status in essential thrombocythemia. | |
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MedLine Citation:
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PMID: 18092959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A retrospective study of 38 essential thrombocythemia (ET) patients was conducted, reviewing bone marrow biopsies according to WHO criteria using a semiquantitative scoring system. Four patients did not fulfil the WHO criteria for a myeloproliferative disorder and one biopsy was insufficient for evaluation. 14 patients were reclassified as having prefibrotic idiopathic myelofibrosis (IMF), whilst the ET diagnosis was sustained in 19 patients. The individual bone marrow parameters of the reviewed diagnosis showed no correlation with JAK2 V617F mutation status, which was determined by a highly sensitive quantitative real-time PCR (qPCR) method. However, we could confirm previous findings of higher haemoglobin and lower platelet levels in the JAK2 V617F positive patients. Thus, the well-established phenotypic relationship of JAK2-positive ET and PV at the biochemical and molecular level was not recorded as regards bone marrow morphology according to the WHO criteria. Accordingly, the WHO concept of two distinct entities, ET and prefibrotic IMF, does not seem to fit the model of JAK2-positive ET as part of a biological continuum of JAK2 V617F-positive chronic myeloproliferative disorders. |
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Authors:
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Thomas Stauffer Larsen; Hans Carl Hasselbalch; Niels Pallisgaard; Michael Boe Møller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 115 ISSN: 0903-4641 ISO Abbreviation: APMIS Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-12-20 Completed Date: 2008-04-01 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: Denmark |
Other Details:
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Languages: eng Pagination: 1267-73 Citation Subset: IM |
Affiliation:
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Department of Haematology and Pathology, Odense University Hospital, Denmark. thomas.stauffer.larsen@ouh.regionsyddanmark.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Amino Acid Substitution Biopsy Bone Marrow / pathology* Erythropoiesis Fibrosis / pathology Granulocytes / pathology Hemoglobins / metabolism Humans Janus Kinase 2 / genetics* Macrophages / pathology Megakaryocytes / pathology Middle Aged Mutation Platelet Count Polymerase Chain Reaction Retrospective Studies Stromal Cells / pathology Thrombocythemia, Essential / blood, genetics*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human |
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