Document Detail


Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias.
MedLine Citation:
PMID:  9694056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 21 bone marrow specimens from 21 patients with systemic lupus erythematosus (SLE) and peripheral cytopenias: anaemia (Hb < 10 g/dl), and/or leucopenia (white blood cell count < 4 x 10(9)/l), and/or thrombocytopenia (platelets < 150 x 10(9)/l). None of the patients had used immunosuppressive drugs in the 2 months before the study, and 11 (52.4%) had never used these drugs. The global and specific series cellularity, degree of fibrosis and necrosis were evaluated by bone marrow trephine; morphological abnormalities and iron stores were evaluated by cytological smears. The most important abnormalities viewed in bone marrow biopsies were: global hypocellularity (47.6%), increased reticulin proliferation (76.2%) with myelofibrosis in one patient, and necrosis (19.0%). The marrow aspirates were difficult to obtain in four patients, who showed an increased reticulin proliferation on histological analysis. Plasmocytosis was present in 26.7% of cases and in one there was a serum monoclonal component (IgG kappa). Iron stores were normal or increased in 26.7% of specimens and decreased or absent in 73.3%. The most frequent peripheral abnormality was leucopenia in 90.4% (19/21) and granulocytic hypoplasia was observed in 47.3% (9/19) of these patients. We conclude that the bone marrow may be a target organ in SLE with cytopenias.
Authors:
R M Pereira; E R Velloso; Y Menezes; S Gualandro; J Vassalo; N H Yoshinari
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  17     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-10-20     Completed Date:  1998-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  219-22     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, University of São Paulo, School of Medicine, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biopsy, Needle
Bone Marrow / pathology*
Female
Humans
Lupus Erythematosus, Systemic / complications*,  pathology
Middle Aged
Pancytopenia / etiology*,  pathology*
Prognosis
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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