| Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. | |
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MedLine Citation:
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PMID: 9694056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied 21 bone marrow specimens from 21 patients with systemic lupus erythematosus (SLE) and peripheral cytopenias: anaemia (Hb < 10 g/dl), and/or leucopenia (white blood cell count < 4 x 10(9)/l), and/or thrombocytopenia (platelets < 150 x 10(9)/l). None of the patients had used immunosuppressive drugs in the 2 months before the study, and 11 (52.4%) had never used these drugs. The global and specific series cellularity, degree of fibrosis and necrosis were evaluated by bone marrow trephine; morphological abnormalities and iron stores were evaluated by cytological smears. The most important abnormalities viewed in bone marrow biopsies were: global hypocellularity (47.6%), increased reticulin proliferation (76.2%) with myelofibrosis in one patient, and necrosis (19.0%). The marrow aspirates were difficult to obtain in four patients, who showed an increased reticulin proliferation on histological analysis. Plasmocytosis was present in 26.7% of cases and in one there was a serum monoclonal component (IgG kappa). Iron stores were normal or increased in 26.7% of specimens and decreased or absent in 73.3%. The most frequent peripheral abnormality was leucopenia in 90.4% (19/21) and granulocytic hypoplasia was observed in 47.3% (9/19) of these patients. We conclude that the bone marrow may be a target organ in SLE with cytopenias. |
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Authors:
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R M Pereira; E R Velloso; Y Menezes; S Gualandro; J Vassalo; N H Yoshinari |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical rheumatology Volume: 17 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-10-20 Completed Date: 1998-10-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 219-22 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, University of São Paulo, School of Medicine, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy, Needle Bone Marrow / pathology* Female Humans Lupus Erythematosus, Systemic / complications*, pathology Middle Aged Pancytopenia / etiology*, pathology* Prognosis Sensitivity and Specificity |
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